ID A0A1S3MUZ6_SALSA Unreviewed; 1737 AA.
AC A0A1S3MUZ6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Alsin-like isoform X4 {ECO:0000313|RefSeq:XP_014006925.1};
GN Name=LOC106575173 {ECO:0000313|RefSeq:XP_014006925.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014006925.1};
RN [1] {ECO:0000313|RefSeq:XP_014006925.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014006925.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014006925.1; XM_014151450.1.
DR GeneID; 106575173; -.
DR OrthoDB; 3740287at2759; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13269; PH_alsin; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR46089:SF3; ALSIN; 1.
DR PANTHER; PTHR46089; ALSIN HOMOLOG; 1.
DR Pfam; PF02493; MORN; 8.
DR Pfam; PF00415; RCC1; 3.
DR Pfam; PF13540; RCC1_2; 1.
DR Pfam; PF02204; VPS9; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00698; MORN; 8.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00626; RCC1_2; 3.
DR PROSITE; PS50012; RCC1_3; 5.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT REPEAT 69..119
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 120..178
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 179..229
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 583..634
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 635..685
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 757..968
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1588..1737
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1516..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1737 AA; 191385 MW; CC253DB3FF63C292 CRC64;
MHQHCHGQIS VMESQRKSSG EEDSSGERGS LHTWKGYSYS VTPERVLLSR PVLQAALGTR
HGVLLVEGGQ VYSFGEFPWK QSQVSEVGPL KPVLESALSG QRVVAVAAGS FHSGAVTEDG
GVHMWGENSF GQCGLSILTV VPNPTPVAVL DPDTSPPHTI RVLELACGEQ HSLALSAQHE
VWAWGSGCQL GLVTTIYPVW KPQKVEHLAG RHVLQVTCGA FHSLALVRCL PPQEARRPLP
DKCGQCNQLL YTMTDKEDHV IISDGHYCPL GVELLADGEA RLGPGRSPPL RLQSSPSEPL
LSSHTSASVP GPYPTITDHT DNERGRTVAQ NGEVLTSTDS DISAAGTDSD RTVGGVGGAA
SQNSPYPDDQ AVKEYLKKLS DTSLAEETAK MTIAGASFQP PADSLDLLTS DLIPGVMPVT
TSSALNSLVS SCASAMGERV VSTYEALSLK KMINYYYPGV GGVAGVPGGV PGGFPGGPAE
ERVRLEESMQ GKKSCSTGDI REEDEGLSRR LSLPGLLSQG RYAVRLLSSS SAHRLLSSLS
SSYTLMLSPR LLRRASRPRV RAVPLTPVGG LPEAGELLPS LQTEVWSWGR GEEGQLGHGD
NLPRLQPLCI KCLSSKEVVL VAAGAHHSLA LTAQSQVFSW GSNSSGQLGH MGCPTTIPRL
AKLSEGIRVW DVGAGAQHTL LLADGDCYQP ILYYSGQQVR EGAQDAPQDQ TEGYSYTQQP
VLLPFCMNLG YVSGVFAGGQ SCVALADRNV MGFIASLHEL AAAERKFYCK LSSVKNHILR
PLLDLGENYR CRYSSAGQRP WVRESLSTAL GPASTVLLQS LARCYSRLCH LTGQHSASLT
ANLRRRREVK SLVMLEHASI FLDTYTEYCC SVGNFLVMGG FQALAKPSLD FFGKCPELLQ
RLAESSEENI PLSDLLVTLF YLPMRHLHEY GRLLLKLGTC FEVSSVDYQK LQDGCSKFEA
LALHLKRRRK EAEYTYHFWK SFPGKMTVSG LDSLRKPRRR LICESSNKAL TLQNSGRFSV
NWFILFNDAL VHAQFSTHHV FPLATLWVEP ILEENTGLYG LKVISPEETF TLLACSSMEK
AKWLRSFNQA VDQAMSGAGQ RAEPPISRTA SYTFYKDSRL KEATYEGHWL AGKPDGRGMM
KWLDGRIYTG TFKNGLEDGF GDYVIPSKTS NLNDHYQGHW KEGKMHGIGT YKYATGELYE
GSFQDNMRHG HGMLRSGTLN SSSPSVFIGQ WVHDKKTGYG VFDDITRGEK YMGMWQDDQR
QGTGVIVTQF GLYYEGAFNN NKMQGTGVLL SEDNTTYEGE FSEDWTLNGK GVLTMANGDY
FEGSFTGEWG SGLKVTGSFF KPNLYHSDGD KGRAVKLGRL AVRPEEKWRA VFEECWMRLG
CEAPGQGENQ RAWENIAEAL TTSRRQHGDS PEMNLSRTHN RTLGSLEFIP QQHVGPVTME
KYDSIRHYLI KACDTPLHPL GRLMETLVAV YRMTYVGVGA NRRLLLQAVN EIMSYLARIF
QLVRFLFPDL PEEGGVIPEP SSDPQDKKDS NCADTQLESP KPGRVVSSSA LLLPVLLPGL
YPPLFTLYVL EKEREDDVYW ECVLRLNKQP DVALLAFLGV QHKFWPVSVP VLGEKTEVVS
STKDACFASA TETLQQIRQF VFSTTFTPSD KLQVIQLTFE EITKEVMSSL EGNFLWSMDD
LFPVFLYVVL RARIRNLGSE VSLIEDLMDP CVQHGEHGIM FTTLKACYYQ IQHEKTT
//
