ID A0A1S3MVQ6_SALSA Unreviewed; 1537 AA.
AC A0A1S3MVQ6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC106575325 {ECO:0000313|RefSeq:XP_014007267.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014007267.1};
RN [1] {ECO:0000313|RefSeq:XP_014007267.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014007267.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC protein kinase family. STE20 subfamily.
CC {ECO:0000256|ARBA:ARBA00008874}.
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DR RefSeq; XP_014007267.1; XM_014151792.1.
DR OrthoDB; 2904475at2759; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06636; STKc_MAP4K4_6_N; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47096:SF1; CNH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47096; MISSHAPEN LIKE KINASE 1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_014007267.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022777,
KW ECO:0000313|RefSeq:XP_014007267.1}.
FT DOMAIN 25..289
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1224..1511
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 305..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1097..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..320
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..337
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 924..939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..992
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 54
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1537 AA; 172359 MW; 0D9B478D14C283D4 CRC64;
MANDSPAKSL VEIDLASLRD PAGIFELVEV VGNGTYGQVY KGRHVKTGQL AAIKVMDVTE
DEEEEIKLEI NMLKKYSHHR NIATYYGAFI KKSPPGHDDQ LWLVMEFCGA GSITDLVKNT
KGNQLKEDWI AYISREILRG LAHLHAHHVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR
TVGRRNTFIG TPYWMAPEVI ACDENPEATY DYRSDLWSTG ITAIEMAEGA PPLCDMHPMR
ALFLIPRNPP PRLKSKKWSK KFCSFIEGSL VKNYNQRPPT EQLLKHPFIR DQPNERQVRI
QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EDAGEQEGEP SSIVNMPGES TLRKDFIRLQ
QENKERSEAL RRQQLLQEQQ LREQEEYKRQ LLAERQKRIE QQKEQRRRLE EQQRREREMR
RQQEREQRRR EQEEKRRMEE MERRRKEDDE RRRAEEEKRR SDREQEYIRR QLEEEQRHLE
ILQQQLLHEQ AMLLPRTLHQ EFKWRELEEQ RKAERLHKRL QQEQAYLLSL QHDNKPPQQT
QPPQPCQKTK DPKGMSPDST SKAPQTTSPG PVGDRAPAPQ PHFLNNSNAI ASRRTSCDNT
RSPQAHFLDN VTANAPRRMS SDTTKSPQTT SRDNTTKAPQ KPSPNSVDKD SEKTPSDHSD
ALATQSTDVT KPSQTGVLDG PKSPQTDRSE PSGALGDPRP IREADERFRK NIQGSPQTAP
PTKQPPVPPR SEPFSNGGSS ESVPPAMHRP MEPQVQWSHL AALKSSSAAP PPVVSRSHSF
SEPAVPSFAH LHLRSQEPHS HHHHPSAAAP SAARTDPQPP ASGPSDEVPP RVPVRTTSRS
PVLSRRDSPL QASAPPSNQA VQRNAGSNAE PRLLWDRVEK LVPRPGSGSS SGSSNSSSQA
GSGERFRARS SSKSEGSPLQ RPDNAAKKPD DKKDFARPNR PADLTALAKE LRAVDDVRPP
NKVTDYSSSS EESGTTDEDD DEEVDQDAAD ESTSGAEDTR AGRGLSNGET ASLKTLLAHD
DSENDLTTPS KDGTLVIRQS AGDKKRPAVN VSSSSSGPSV AHGQAVQVHT PPGPGNGHQE
KNGFAGRIHL LPDLIQQSHH SPTSSSSSIS NSPSSSSSHV SPAMSPQTPL DKLTAIETQS
ASNTMQKHKS SSSFTPFIDP RLLQVSPSSG SSLNNMAAFG NDGRLVDALR ADPSRKGSVV
NVNPVNTRPQ SDTPEIRKYK KRFNSEILCA ALWGVNLLVG TESGLMLLDR SGQGKVYPLI
SRRRIQQMDV LEGLNVLVTI SGKKNKLRVY YLSWLRNKIL HNDPEVEKKQ GWVTVGELEG
CVHYKVVKYE RIKFLVLALK NSVEVYAWAP KPYHKFMAFK SFGDLVHKPL LVDLTVEEGQ
RLKVIYGSSN GFHAVDVDSG AVYDIYLPTH IQTNIQSHAI IILPNTDGIE LLVCYEDEGV
YVNTYGRITK DVVLQWGEMP TSVAYIRSNQ IMGWGEKAIE IRSVETGHLD GVFMHKRAQR
LKFLCERNDK VFFASVRSGG SSQVYFMTLG RTSLLSW
//
