ID A0A1S3MXV3_SALSA Unreviewed; 219 AA.
AC A0A1S3MXV3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein N-lysine methyltransferase METTL21A {ECO:0000256|ARBA:ARBA00040801};
DE AltName: Full=Methyltransferase-like protein 21A {ECO:0000256|ARBA:ARBA00041632};
GN Name=LOC106575836 {ECO:0000313|RefSeq:XP_014008002.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014008002.1};
RN [1] {ECO:0000313|RefSeq:XP_014008002.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014008002.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:54192, Rhea:RHEA-COMP:9752, Rhea:RHEA-
CC COMP:13826, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961;
CC Evidence={ECO:0000256|ARBA:ARBA00024593};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54193;
CC Evidence={ECO:0000256|ARBA:ARBA00024593};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL21
CC family. {ECO:0000256|ARBA:ARBA00038029}.
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DR RefSeq; XP_014008002.1; XM_014152527.1.
DR AlphaFoldDB; A0A1S3MXV3; -.
DR STRING; 8030.ENSSSAP00000037382; -.
DR PaxDb; 8030-ENSSSAP00000037382; -.
DR Ensembl; ENSSSAT00000063151; ENSSSAP00000037382; ENSSSAG00000042982.
DR GeneID; 106575836; -.
DR KEGG; sasa:106575836; -.
DR CTD; 151194; -.
DR OMA; FQLRQDW; -.
DR OrthoDB; 5346852at2759; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR Bgee; ENSSSAG00000042982; Expressed in zone of skin and 15 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN; 1.
DR PANTHER; PTHR14614:SF14; PROTEIN N-LYSINE METHYLTRANSFERASE METTL21A; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_014008002.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|RefSeq:XP_014008002.1}.
SQ SEQUENCE 219 AA; 24225 MW; EE4285BE4093361F CRC64;
MALVPYDGNY LPVLSKLHNS SAEFHFADHN VRLTQDWNKL GVAAVVWDAA VVMCMYLELG
QVELTGKVAI ELGAGTGLVG IVAALLGAKK VTITDREPAL GFLAANVKEN IPPDQLGAVE
VSELTWGQGL ERYPTGGFDI VLGADIVYLE DTFPSLLQTM EHLSSESSVV LLACKIRYER
DTNFLSMLKQ RFTVHEVHYD KERDIHIYKA VKLPARRDL
//
