ID A0A1S3MYS4_SALSA Unreviewed; 414 AA.
AC A0A1S3MYS4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Transcription factor EC {ECO:0000256|ARBA:ARBA00019430};
GN Name=LOC106576052 {ECO:0000313|RefSeq:XP_014008369.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014008369.1};
RN [1] {ECO:0000313|RefSeq:XP_014008369.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014008369.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR RefSeq; XP_014008369.1; XM_014152894.1.
DR AlphaFoldDB; A0A1S3MYS4; -.
DR OrthoDB; 3061893at2759; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18926; bHLHzip_MITF; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR PANTHER; PTHR45776:SF1; TRANSCRIPTION FACTOR EC; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 180..233
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 290..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 233..267
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 414 AA; 46387 MW; 6DEB148AE4BBB395 CRC64;
MLEYNWYGQV QSHLEGSKFH LHQAQSQQVK QYLTLGSKVA GGQGGHPHPT GQGGQLLGTV
PVMRNCHMAP LSDGSTPSSP VTLLTLASNH DSEFPMDEVI DDLISLESGF NDRGLDCMDP
SIIMQNNVLS SSMLDIYGGE PGMTTAPHSR MTPTLRPTML TTVKREVTEH ETRVMAKERQ
KKDNHNLIER RRRYNINYRI KELGTMIPKS NDPDMRWNKG TILKASVEYI KWLQKEQQHT
RELENRQKKM EHANRKLLLR IQELEIQARA HGLPSMATAL GTVELSSHLL KQQKQQQQEP
LAPQSQQGLQ PPLYQEELNG EYLQRTSMPA MVTGLTDQGQ GVVDGSTTFS DPLSHFTDFF
SSTLKEEQRL DEILMDNPLS PFGTDPLLSA GSPDASKDSS HRSSFSSDDG DDDL
//
