ID A0A1S3MZS3_SALSA Unreviewed; 2674 AA.
AC A0A1S3MZS3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Filamin-C-like {ECO:0000313|RefSeq:XP_014008672.1};
GN Name=LOC106576205 {ECO:0000313|RefSeq:XP_014008672.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014008672.1};
RN [1] {ECO:0000313|RefSeq:XP_014008672.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014008672.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR RefSeq; XP_014008672.1; XM_014153197.1.
DR STRING; 8030.ENSSSAP00000095381; -.
DR PaxDb; 8030-ENSSSAP00000095381; -.
DR KEGG; sasa:106576205; -.
DR OrthoDB; 298396at2759; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21310; CH_FLNC_rpt1; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537:SF12; FILAMIN-C; 1.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 23.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 23.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 23.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 23.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..151
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 168..271
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 279..377
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 379..477
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 552..603
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 607..703
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 704..806
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 807..905
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 906..1001
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1002..1094
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1095..1189
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1190..1289
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1290..1382
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1383..1478
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1479..1575
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1588..1679
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1728..1797
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1797..1889
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1887..1976
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1979..2071
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2164..2253
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2256..2348
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2350..2443
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2447..2539
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2579..2673
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2123..2143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2176..2212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2176..2205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2674 AA; 287998 MW; F2F7AD99A23AEFBE CRC64;
MMSNNTYYEQ QQPPQYYQST DNGDDEEEEM PATEKDLAED APWKKIQQNT FTRWCNEHLK
CLNKRINDLQ KDLTDGLKLI GLLEVLSQKK MYRKYHARPN FRQMKLENVS VALEFLEREH
IKLVSIDSKA IVDGNLKLIL GLIWTLILHY SISMPMWEDE DDEDAKKLTP KQRLLGWIQN
KVPQLPINNF HRDWRDGKAL GALVDNCAPG LCPDWETWDP SQPVENAREA MQQADDWLGV
PQVIAPEEIV DPNVDEHSVM TYLSQFPKSK LKPGAPLRSK TLHPKKAKAY GPGIDPRGNM
VLKPAEFIVE TVEAGLGEVL VYVEDSEGHT EEARVIPNND KNRTYSVIYL PKVEGLHKVK
VLFAGQDIDR SPFVVSVSKA MGDPNKVQAR GPGLEPVGNV ANKPTYFDIY TAGAGAGDVG
VIIVDSQGRR DTVEIILENK GDSIFRCTYC PILKGPHVIY VTFAGQQIPR SPFTVHISEG
NTHTHTHTHT HTHTHTHTHT LEASVAIYAC LSLCCQCICV RFCVCVSLYL YPPLYNVYLY
LSPCLCSSPG FSIEGPSQAK IECDDKGDGS CDVRYWPTEP GDYAVHVICD DEDIKDSPFM
AHILLTANDV FPEKVKSYGP GLEPIGCIVN KPAEFTIDAS GAGRGQLKIY AQDAEGFPID
IQITENGDST FLCVYIPTKP IKHTIIITWG EVNVPNSPFR VTIGEGSHPE NVKVYGPGVE
KSGLKANEPT YFTVDCSEAG QGDVSIGIKC APGVVGPAEA DIDFDIIKND NDTFTVKYMP
PGPGRYTIMV LFADHEIPIS PFRIKVDPSH DANKVRAEGP GLNKTGVEVG KPTHFTIYTK
GAGKAKPEVH FTGAAKGDAV RDFEIIDNHD YSYTVRYTAV QQGNMSISIC HGGDPIPKSP
FNITVAPPLD LNKVKVQGLN NKVDVGKDQE FTVNTHGAGG QGKLDVKITS PSRRPIPCKL
ESDTANEVHT VKYIPPEEGP YKVDISYDGN PVPGSPFTVE GVMPPDPSKV RAYGPGLQGG
MVGKPAPFAI DTKGAGTGGL GLTVEGPCEA KIECQDNGDG SCSVSYLPTE PGEYAINILF
AEQHIPGSPF KAMVQSVFDP SKVTASGPGL ERGKVNEAGS FIVDCSKAGE AELTIEIISD
SGSKVEVRVQ NNSDGTYSIT YIPQFHGMYT ITIKYGGHAV PKFPARVQVD PAVDTSGVKV
YGPGVEPRGV LREVTTHFIV DARAKSKTGG SHVKARIVNP SGANTDAYIT DKGEGTYRVE
YAAYEDGMHL IEVLYDDVAV PNSPFRVPVT EGCDPSRVRA YGPGLEEGLV NKPNRFTVET
RGAGTGGLGL AIEGPSEAKM SCKDNKDGSC SVEYLPFTPG DYDVNITFGG LPIPGSPFRV
PVGELVDPSK VRCSGPGLGS GVRARVPQTF TVDTSKAGLA PLGVVLYGPT GVAEPVNITD
NGDGTHTATY TPAKDGPYTV CVKYADQEVP RSPYKIKTLP AHDASKVRAS GPGLNAQGVP
ASLPVEFTID ARDAGEGLLT VQILDPEGKP KKANIRDNRD GTYTVSYVPD MAGRYTITIK
YGGDEIPYSP YRIHALPTGD ASKCLVTVSI GGHGLGSGLG PTIQIGEETV ITVDAKAAGK
GKVTCKVSTP DGAELDVDVV ENSDGTFDIY YTAPEPGKYV ITIRFGGEHI PNSPFHVVAS
DTVPIIEEPC DKLQLQQPYQ AYQGYPPHWA TEEPVTPGDI MEPMLRPFNL VIPFTVQKGE
ITGEVRMPSG KTARPNITDN KDGTVTVKYA PTEKGLHEMD IKYDGNHIPG SPLQFYVDAI
NSGHVTAYGP GLSHGMVNKP ATFTIVTKDA GEGGLSLAVE GPSKAEINCK DNKDGTCTVS
YLPTVPGDYN IIVKFDNKHI AGSPYTAKIT GDDTMRTSQL NVGTATDVSL KISETDLSSL
TASIRAPSGN EEPCLLKRLP NRHIGISFTP KEVGEHVVSV KKNGTHVTNS PFKIMVGQSE
IGDASKVKVF GQGLVEGHIF EVAEFIVDTR NAGYGGLGLS IEGPSKVDIN CEDVEDGTCK
VTYCPTEPGN YIINIKFADQ HIPGSPFTVK VCGEGRVKES ITRKRHAPSI ATVGSTCNLN
LKIPGNWFQM VSAQERHTRT FTRSSHTYTR TERTEISKTQ AGETKREVRV EESTQVGGDP
FRDVFGEFLG SQSLTGFSGI PATTRQSQEG DQGTQEMTAQ VTSPGGKTED AEIIDGEDST
YSVRFIPQEM GPHTVNVKYR GQHVPGSPFQ FTVGPLGEGG AHKVRAGGTG LDRGVAGVAA
EFSIWTREAG AGGLSIAVEG PSKAEITFED RKDGSCGVAY VVQEPGDYEV SIKFNDEHVP
DSPFIVPIAT LSDNARRLTV TSLQEMGLKV GQEASFAVQL NGARGLVDAK VHTPSGAVEE
CYVTELDSDQ HAIRFIPREN GVHSIEVRFN GSHIPGSPFK IRVGEIGQVG DPGMVSAFGP
GLEGGTTGVA SDFVVNTCNA GSGALSVTID GPSKVKMDCQ DCPEGYKVTY TPMAPGSYLI
TIKYGGPSHI VGSPFKAKVT GKSLSLSLSL FSLSVLVETV TKSLSSSSSS SMGVAYGPKF
SSDASKVVSR GAGLSKAFVG QKNTFTVDCS KAGTNMLMVG VHGPKTPCEE VYVKHLGNRM
YNVTYTVKEQ GNYILIVKWG DENVPGSPFH VTVP
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