ID A0A1S3N0A7_SALSA Unreviewed; 1366 AA.
AC A0A1S3N0A7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 6-like {ECO:0000313|RefSeq:XP_014008862.1};
GN Name=LOC106576296 {ECO:0000313|RefSeq:XP_014008862.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014008862.1};
RN [1] {ECO:0000313|RefSeq:XP_014008862.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014008862.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_014008862.1; XM_014153387.1.
DR STRING; 8030.ENSSSAP00000065073; -.
DR PaxDb; 8030-ENSSSAP00000065073; -.
DR Ensembl; ENSSSAT00000237717; ENSSSAP00000170433; ENSSSAG00000058619.
DR GeneID; 106576296; -.
DR KEGG; sasa:106576296; -.
DR OMA; EDRVAHW; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR Bgee; ENSSSAG00000058619; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15743; FYVE_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 818..1007
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1036..1130
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1168..1227
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1269..1365
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 778..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..32
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..87
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..324
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..375
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..575
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1366 AA; 151558 MW; C333E1BDE3E9F00B CRC64;
MSTGVKKPPV APKPKLAPLV KLSPPPIAPK PDLLLSQPSQ PSPLLTQPSP AVLKRAKPAV
APKPCLSKPS APAAPASPPP PRPRVPQTPS QECSGAGDDS LSFLNSRNGI LSQPILHDSD
YIIPTCSCGL QDCSQCKRLG NGNVTEVGSD TLGSWPNRNA TESTGTLVAN RPGKTENGDS
EKSGGVTNTL RLRLKDKPQR QEGQRDGEGS RDEEKLQGNK EERPRNQKGQ EGQQYQTGSG
DQSCNVPEVA ETLTQTETKA SNAERTYTDS CNIDSNESDT IPTPLILPLD VSPIHTPPQT
VPPTRTPSQT VPPTRSPPQI LPPSLTPTQM DSEPDSTPSH ADSSTQCSRI PRLPTDLSVP
AAPSKPLPVP LPRKPRKPAL VRQDGLEAST QEGETKNRTQ GGEVGETEGS GGRCLTSDKE
EHTQGVYDSP SPSQDPEVEE EPHPVPPPRQ KSLSPRLHRA SLNRNTSHSL DLLSQPELNA
LTSERRGGGD EEEEKEEEVE DGYGDFERYP ITRSLPKQIK LSCRPPPVGM TMKASSAEEG
GSPRAPPRKP QRHSLPAGAP PSITPPPPPP HHANTPMREL PATPQEKPAW RFPRPFFSRQ
SSSRHSSGGR GAPQGKAALL GGKQRAQSFS SADLLARADG TKRSLSFRKL LELRLSVRML
PRLLARSGQS LDCTSVEPGG GGRTVDQSDG SAGVSGRDGE GSVEYENVPL YEEIPEYMNL
PFLSARLGWP LTHSLDPSTH RHSDSDVYEV QDPYESHCDY KRPHSIDYER GWHGLDDAHS
EEEVHSSDED DNSSTSSKEH LELSEEDRQQ EDEVKRKKMV HIAQEIMSSE KVFVDVLKLL
HIDFRDAVAK ATRQNGKPVV EERILTQILY YLPQLYQLNR DLLRELEERV ARWGDHQRLA
DIFVQKGPYL KMYSTYIRQF DNNVAMLDEQ CRKNPGFAAV VREFEMSPRC ASLALKHYLL
KPVQRIPQYQ LLLTDYLKNL PEDSSDYKDT QAALGIVKEV ANHANDIMKQ GDNFQKLMHI
QYSLNGQHEI VQPGRVFLKE GTLMKLSRKV MQPRMFFLFN DTLLYTTPVQ SGQYKLNSML
SLAGMKVSKP SQEAYQNELN IESVERSFIL SASSATERDE WLAAIATAID DHTRKKITFI
SSRSQEEADG VCDSGAPLGS KAPIWIPDLR ATMCMVCTCE FTLTWRRHHC RACGKVVCQT
CSSSKFYLEY LKNQPARVCD HCFVKLQENS DRVASGALSP TGRSGGFSFS RKQKKIPAAL
KEVSANTENS SMSGYLQRSK GNKKQWKRLW FVIKNKVLYT YAASEDVAAL ESQPLLGFFL
REEKCGPFQK LQFKLYHKNT LFYIFKADDI PTAQRWIEAF QEAMIL
//
