ID A0A1S3N1Y7_SALSA Unreviewed; 922 AA.
AC A0A1S3N1Y7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=LOC106576405 {ECO:0000313|RefSeq:XP_014009031.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014009031.1};
RN [1] {ECO:0000313|RefSeq:XP_014009031.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014009031.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR RefSeq; XP_014009031.1; XM_014153556.1.
DR AlphaFoldDB; A0A1S3N1Y7; -.
DR GeneID; 106576405; -.
DR OMA; PRTEPEW; -.
DR OrthoDB; 534027at2759; -.
DR Proteomes; UP000087266; Chromosome ssa17.
DR Bgee; ENSSSAG00000017632; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR InterPro; IPR032394; Anoct_dimer.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF28; ANOCTAMIN-4; 1.
DR Pfam; PF16178; Anoct_dimer; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 316..343
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 392..411
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 465..484
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 515..535
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 563..582
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 603..622
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 683..705
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 733..757
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 77..302
FT /note="Anoctamin dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16178"
FT DOMAIN 305..887
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 886..920
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 38..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 107710 MW; A2098F4173986DDE CRC64;
MEVSLAGAPD SPSTQDNVPP HVLKDVKLLM ESLEGLSTPS KDGDSTLLDP GTSSILDDNT
RTDPAPEVGR SRSSGLCFSD GKCHIDYILV YRKSGPQSEK REIFERNIRA EGLQMEKELS
VCNSDVIFLK LHAPWEVLCR YAELMNIRMP FRRKIYYMHR RYKFMSRMEK RINRFRGWLP
RKPMKFDNNT LPDLEENESF TAPFSRSRIH HFTIHNKDTF FNNATRSRIV HHILQRVKYE
EGKDKMGLNR LLSNSSYEAA FPLHEGSYRS KNSIRTHGAE NHRHLLYECW AWWGVWYKYQ
PLDLIRRYFG EKIGLYFAWL GWYTGMLFPA ALVGLMVFLY GWFTLDHCQV SKEICQATDI
IMCPICDEYC PYLRLSDSCI YAKVTHLFDN GATVFFAVFM AVWATVFLEF WKRRRAVLAY
DWDLIDWEEE EEEIRPQFEA KYSKKERMNP ISGKPEPYQA FTDKYSRLIV SASGIFFMIL
VVIAAVFGIV IYRVITVSTF AAFGWALIRN NSQVATTGTA VCINFCIIML LNVLYEKVAL
LLTNLEQPRT ESEWENSFTL KMFLFQFVNL NSSTFYIAFF LGRFTGRPGA YIRLINRWKL
EECHPSGCLI DLCMQMGIIM VLKQTWNNFM ELGYPLIQNW WTRRRLRQEH GPNAKASFPQ
WERDYNLQPM NAYGLFDEYL EMILQFGFTT IFVAAFPLAP LLALLNNIIE IRLDAYKFVT
QWRRPLPSQA KDIGIWYGIL EGIGILSVIT NAFVIAVTSD FIPRLVYAYK YGPCAGQGRA
GERCMMGYVN ASLSMFRVSD FENTSVPRTD GSDMFGEAVK YCRYRDYREP PDSPGEPYSY
TLQFWHVLAA RLAFIIVFEH MVFTIKNLIA YLIPDLPKDL RDRMRREKYL IQEMMYEAEL
ERLQKEKNEK KKNYRAHHNA LP
//
