ID   A0A1S3N2R2_SALSA        Unreviewed;       328 AA.
AC   A0A1S3N2R2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Epithelial cell adhesion molecule isoform X1 {ECO:0000313|RefSeq:XP_014009610.1};
GN   Name=epcam {ECO:0000313|RefSeq:XP_014009610.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014009610.1};
RN   [1] {ECO:0000313|RefSeq:XP_014009610.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014009610.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   RefSeq; XP_014009610.1; XM_014154135.1.
DR   AlphaFoldDB; A0A1S3N2R2; -.
DR   Ensembl; ENSSSAT00000002913; ENSSSAP00000002712; ENSSSAG00000067375.
DR   GeneID; 106576762; -.
DR   KEGG; sasa:106576762; -.
DR   OrthoDB; 5305981at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa18.
DR   Bgee; ENSSSAG00000067375; Expressed in nose and 15 other cell types or tissues.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR   InterPro; IPR049420; EPCAM-Trop-2_C.
DR   InterPro; IPR043406; EPCAM/Trop-2.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   PANTHER; PTHR14168; TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER; 1.
DR   PANTHER; PTHR14168:SF4; ZGC:110304; 1.
DR   Pfam; PF21283; EPCAM-Trop-2_C; 1.
DR   Pfam; PF00086; Thyroglobulin_1; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR   PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        285..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          80..158
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
SQ   SEQUENCE   328 AA;  36767 MW;  F4F054DE1A15A0C1 CRC64;
     MKRFLTTASY SNIRYNVVAV SVCTAMKIWI ALLLATFAVG ASAQCTCESF KWATCDGTPC
     QCGVMVGTGE KQNLNCSKLI PKCFLMKAEM YRARNGLSTR TGGKPVKTAF VDNDGIYDPD
     CETTGAFRAK QCNNTKECWC VNSAGVRRTD KGDESLRCEK LVETYWVRLE LKHKPVNNAV
     DAAKLQAAIA TAIQNRYSFD KTLVKEVEYD PEARLIVVDV QKERGDRKAD LSRMAYYMEK
     DVKVLPLFND QAKFEPSVDG QKLEMEDILV YYVDEEAPTF TMKRLTGGVI AVIVVVILAV
     AAGLLVLYLK RRRERGYSKA EPREMEAM
//