ID A0A1S3N2R6_SALSA Unreviewed; 725 AA.
AC A0A1S3N2R6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=DNA mismatch repair protein Mlh1 {ECO:0000313|RefSeq:XP_014009769.1};
GN Name=mlh1 {ECO:0000313|RefSeq:XP_014009769.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014009769.1};
RN [1] {ECO:0000313|RefSeq:XP_014009769.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014009769.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR RefSeq; XP_014009769.1; XM_014154294.1.
DR AlphaFoldDB; A0A1S3N2R6; -.
DR STRING; 8030.ENSSSAP00000119639; -.
DR PaxDb; 8030-ENSSSAP00000119639; -.
DR GeneID; 106576838; -.
DR KEGG; sasa:106576838; -.
DR CTD; 4292; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000087266; Chromosome ssa18.
DR Bgee; ENSSSAG00000081122; Expressed in zone of skin and 15 other cell types or tissues.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 213..332
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 391..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 81576 MW; 480E67312A7EDCD5 CRC64;
MSGVIRRLDE TVVNRIAAGE VIQRPANAIK ELLENCLDAK STNIQVTVKE GGLKLIQIQD
NGTGIRKEDM EIVCERFTTS KLQTFEDLNA ISTYGFRGEA LASISHVAHV TITTKTADAK
CAYRATYCDG KLKTQPKPCA GNQGTQITAE DLFYNVSTRR KALKSPSEEY SRIVEVVSRY
AIHNSGKSFA VKKQGETMAD VRTLPNASTL DNIRVVFGNT VSRELIEVGC EDQKLAYKLK
GHISNANYSV KKCILILFIN HRLVESSALK KAIETVYAAY LPKNSHPFLY LSLEIAPHNI
DVNVHPTKHE VHFLHEDCII ESVQKHIESK LLGSNSSRTY FTQTLLPGLS VSTSEGKSSS
NSTGDSERVY AHQMVRTDSR AQKLDAFLQP ASKLAPTPTA NPNGQSRGEP VTTNDMEEMD
NAEILEEQAP GATEDEEGTS LNTPADLPRK RPRAGQDEEQ EDLTAAATTR RRAIKLSSVK
ELRDDIAEHA HKGLQEMLQN HSFVGCVNPQ WTLIQHHTKL YLLNTTKLSQ ELFYQILIYD
FGNFGILRLS EPAPLYDLAM LALDSEESGW SEEDGPKEGL SQYIVDFLKK KSEMLEDYFS
MEIDQEGNLT GLPLLLDKYT PPMEGLPMFI LRLATEVNWD NEKDCFRDFS KECSQFYSIR
KQYVLELEPG EEEQDAELNS WRWKVEHLLF KAFRSLFSPP KHFSEDGSVL QIANLPDLYK
VFERC
//
