ID A0A1S3N4Z3_SALSA Unreviewed; 4066 AA.
AC A0A1S3N4Z3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Ankyrin-3-like isoform X12 {ECO:0000313|RefSeq:XP_014010395.1};
GN Name=LOC106577144 {ECO:0000313|RefSeq:XP_014010395.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014010395.1};
RN [1] {ECO:0000313|RefSeq:XP_014010395.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014010395.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_014010395.1; XM_014154920.1.
DR OrthoDB; 5474900at2759; -.
DR Proteomes; UP000087266; Chromosome ssa18.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08803; Death_ank3; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR037971; Ank3_Death.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 4.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 75..107
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 108..140
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 141..173
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 174..197
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 244..276
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 277..309
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 310..342
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 343..375
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 376..408
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 409..441
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 442..474
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 475..507
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 508..540
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 541..573
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 574..606
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 607..639
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 640..672
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 673..705
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 706..738
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 739..771
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 772..804
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1003..1158
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1160..1307
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 3451..3535
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1931..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1990..2011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2045..2076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2109..2149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2342..2383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2419..2461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2489..2515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2533..2647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2660..2748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2869..2903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3001..3327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3362..3414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3610..3629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3676..3708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3791..3965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4013..4066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2049..2076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2111..2128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2359..2381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2422..2448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2533..2568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2569..2585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2586..2604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2627..2647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2667..2683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2690..2709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2719..2738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2870..2903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3001..3023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3055..3073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3155..3193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3215..3229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3255..3274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3275..3290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3299..3321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3362..3377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3380..3407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3859..3905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3913..3933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3934..3965
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4045..4066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4066 AA; 446527 MW; 23D47C97C1C0E90D CRC64;
MAHAASALKK NRDVDVNAIE DEKEKKRRIK KLASREQKRK SDSNASYLRA ARAGNLEKAL
DYLKSGVEIN ICNQNGLNAL HLASKEGHVE VVAELLKLEA NVDAATKKGN TALHIASLAG
QTEVVKELVT NGANVNAQSQ NGFTPLYMAA QENHIEVVRF LLEHNSSQSM ATEDGFTPLA
VALQQGHDQV VSLLLENDTK GKVRLPALHI AARKDDTKAA ALLLQNDRNA DVESKMMVNK
TTESGFTPLH IAAHYGNINV ATLLLNRGGA VDFMARNDIT PLHVASKRGN SNMVKLLLDR
GSKIDAKTKD GLTPLHCGAR SGHEQVVEIL LDRGAPILSK TKNGLSPLHM ATQGDHINCV
QLLLQNDVPV DDVTNDYLTA LHVAAHCGHY KVAKLIVDKK ANPNAKALNG FTPLHIACKK
NRAKVMELLL KHGASIQAVT ESGLTPIHVA AFMGHENIVN SLTHHGASPN TTNVRGETAL
HMAARAGQAD VVRYLLQNGA KVETKAKDDQ TALHISSRLG KADIVQQLLQ RGASANAATT
SGYTPLHLAA REGHEDVAAM LLDQGASLSA STKKGFSPLH VAAKYGKMEV ASLLLQKRAA
PDAAGKSGLT PLHVAAHYDN QRVALLLLDQ GASPHAAAKN GYTPLHIAAK KNQMDIGTTL
LEYGADTNAV TRQGISPVHL AAQEGSVDLV SLLLTKNASV NMGNKSGLTP LHLAAQEDKV
NVAEVLLNQG ADVDPSTKMG YTPLHVACHY GNVKMADFLI QNQARVDDKT KNGYTPLHQA
AQQGHTHIIN LLLQHGASAN QLTVNGSTAL SIACRLGYIS VVDTLRPVTD ENLTSVTATE
KHKMNIPETM NEFLDMSDDE AKANAPEILN DDCISDVDEG EDAMTGDTDK YLRPQDLKEL
GDDSLPQEGY MGFSIGVRSA SLRSFSSDRS NTLNRSSYAR DSMMIEEILA PTKDTHLAVT
RDYDAECLRR YSWTPDTIDH SNTVSSPIHS GLSSPLPQYD SRFLVSFMVD ARGGSMRGSR
SNGMRIIIPP RKCTAPTRIT CRLAKRHKLA YPPPMVEGEG LVSRLVEVGP AGAQFLGPVI
VEIPHFGSMR GKERELIVLR SDNGDTWKEH QYDCHPSDIT DILNGMDEEL DSNAELEKKR
ICRIITRDFP QYFAVVSRIK QESNHMGPEG GTLTSLTMPM VQASFPQGAL TKKIRVGLQA
QPVPDDMVRN LLGNRATFSP IVTVEPRRRK FHKPITMTIP VPPRSAEGHP IGPRGDSTPC
LRLLCSITGG TSPAQWEDIT GTTPLSFVTD CVSFTTNVSA RFWLADCHQI PETVGLASQL
YRELICVPYL AKFVVFAKMN DPVESRLRCF CMTDDKVDKT LEQQENFEEV ARSKDIEVLE
GKPIHVDCYG NLSPLIKSGQ QLIFNFFSFK ENRLPFNVKV RDMGQEPCGR LSFLKEPKTT
KGLPQTAICN LNITLPTHKK DMMESDPDDE TEKPDRRHTF ASLALRKRYS YLTDPAAKTT
DRSSQRTQPT GYAYKPVFST RSYQAWSAVP VSVPEQAKSG FGSHSSSSSN TPNASPLKSV
WSITSASPIK SNIGCSPAHS IKSVSDVASP IRSYRTISSP IKTVVQQTQY PVQVTPSLLS
SPVRSVPDPV SIKGLAALSS RTSPISTGVG CLLERSSIAM SPPASPKSSL NMYSSTLPFK
GVMVGTTASS SPIKTVPGLS SVRSNADPLS LFSSLSSPIK SNTPPSAAAL INGTVSPTKY
RSSSPTSLLS SSLQERIQAT TNAATTSVNA AFDEVEKTFN SCSASGYGTL KSMSSSASSS
YQSIRSSASS SLYATLRSPP NSTTTVTSGT MTVPVYSVIN VLPEPQFKKL PEVSTPAAAL
SSSRKTMPAE TNSAQSSFAR TLSPVKSPLF MPPTALKSTT SSPLSSSQEI LKDVAEMKED
LIRMSNILQT EPSSASKGFQ SDSPKEAKIE DEEPCRIVEK VKQDLVKVSE ILTKDTVKDS
KTAIKMNKTD EAQCSKQAPV DPQPSNWSYP PRYETVVPQI KTKTIPDRDF NLLKVVDYLT
NDIDSGSISK TADAKHKSDE VRREGEEKQK RMLKPEHKLK MPPANMRSSA SEKELCKLAD
VLFGPDAMLE SPDDISHDQD KSPLSDSGFE TRSERTPSAP QSAEGMGPKA LFQDIPPVIT
ETRTEVVRVI RSYESPEDNK QPMMEDTRAV RYTDAEPKVL NASNVDQTKS FQMKISPDDD
SMGKSMRVKE ETHITTTTRM VYHKPQSKEN ASERMEESMS VHDIMKAFQS GRDPSRELAG
LFEHRAGNDD TSQRDINSKP KVERIIEVHI EKGNKTEPTE VIIRETKNAP EKEMYFYQGN
SGLSRQGEEE PEESLPCYLE SSRVNTPMSQ EDDSRPSSAQ LMADDSYKAL KLLSQQSVEY
NDDESSELRG ESYNFADKML LSEKPDSSHS DTEEYLRDRS HFHSPDRSSY SQERSSGSRQ
EYILRSSNID KSGENANVDD NFDKLTLLQY SSEPGSPKHS VWMRVTDDRQ SQNREKLIYE
DRVDRTVKEA EEKLSEVSQF FRDKTEKLND ELSSPEKKSR RSDFRETRSG PSSTHSSPER
STYKNGSSGE ECRERFRDRF GSSDRKCASL PSSPERRVLL QYNDDNRKPG DGTSQGNAGD
ASKPFQMSCS KVSAVRLKFE QEAQKQEKGP QWGQTSNAPV RKLQESTLPV YQVFAGSNIP
KSPDSPGSTR KVIESEVRGS SGPSPSANRY ICSSPKHDTN GNEQEEKKSF KTWECHGNGN
YKPQVSKLAH TLVQDAHGND RNSQRQLQGF RDGITSKEET TKKTIYTELV VRENPNSSDV
RTGSLKKNSE SQIPVRMPCS FSENHQSTSL KLDTSVKLCE RAGSQIPTLA RNRLHGSSEA
NKSTNDSSVE KSSDSYDSSQ STVVCNGIDS DQVEYLENIT PVVVTEGFKD IKPLPVYVSI
QVGKQYEKET TGLLGTYQKI VSHESRTVHE TRGAFYTVKQ KQPPSPQGSP EDDTLEQVTF
MDSSGKSPVT PETPSSEEVS LASRKTDSVI GYMPSMPSPI AEESEEDEGK TFIYTESLPQ
KTKPASSEPS NRNQETLKRP KEKRVAYIEF PPPPPLEAEH SDPEKRGSCA SSEAETEMME
VNLQEEHDQH LLAEPIIRVQ PPSPVPPGAD DSNSSDDESI FHPIPNKKYT FKMKEKEEGE
KRLKPKKPER NGNNKESGTN GVVKAEEEDL EQNDQSITDC SIATTEFSHD TDATEIDSLD
GYDLQDEDDG LSEQDPKTSS LSNDGKTCDR SFSQSKLEVI EEEKTPSEDG GDNGKANSDQ
NIGDEKDYTL EGRHPDRQGD RQGFADNFFG YQLEEELNST FKTVATKGLD FDPWSSKGGE
GVFDAKAKEE DPKPFGLSVD DKSQATTPDT TPARTPTDES TPTSEPNPFP FHEGKMFEMT
RSGAIDMSKR DFVEERLQFF QIGPQSPCER TDLRMAIVAD HLGLSWTELA REMDFSVDEI
NHIRVENPNS LTAQSFMLLK KWVSRDGKNA TTDALTGVLT KVNRMDIVTL LEGPIFDYGN
ISGTRSFADD NAVYLDQADD YHSILAELQS PVQLHSDPPF TELHSEPPTL TIDPTPVQLH
PHPPTLILTQ SEPWNDHMEP SVDPDTSTRT TLRPWELSLS IHTLHLDPTA ATNTGMAEGD
QVLMVQVEEE KKEVDISLQH QEDSRQTGAS AVVAEGEAEE EAEEVVKGGG EEGVEVGEMA
EEGDKVVEAK IGAKVVEGGK VAEEGAKVRV EGGKVEWAKV RVEGAKAVEN GAEVVEEGGA
YLSPQAWAEA LGEQGVSGST EEEDGDEDEK TEDKLKSLLE DIHLEEGSEE EDEEMTEARV
QEIVSQVQQA EKDVCSLPGW HSDTSSVNVE PPTPGRSVSS DLLDRQENSQ ENSSDSITSS
SRGEPARSRH NGDNTELPPQ DGSLPVSQDS ANGRTGRGKE EGTLVSERKV QQHFSESGSD
EERTVTTRVF RRRVILKGEQ AKNIPGESVT EEQFTDEDGN IITRKVIRKV IRRVSTPTPD
DQGGDRGSWD RGDPWPCPFL LEEELEQGDG AKSRKEERSG EKKLQS
//
