ID A0A1S3N7F0_SALSA Unreviewed; 1562 AA.
AC A0A1S3N7F0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Latrophilin-3 isoform X4 {ECO:0000313|RefSeq:XP_014011364.1};
GN Name=adgrl3 {ECO:0000313|RefSeq:XP_014011364.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014011364.1};
RN [1] {ECO:0000313|RefSeq:XP_014011364.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014011364.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_014011364.1; XM_014155889.1.
DR OrthoDB; 1114672at2759; -.
DR Proteomes; UP000087266; Chromosome ssa18.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd22846; Gal_Rha_Lectin_LPHN3; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF60; ADHESION G PROTEIN-COUPLED RECEPTOR L3; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1562
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010222846"
FT TRANSMEM 868..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 903..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 927..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1010..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1054..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1083..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..124
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 137..396
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 488..545
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 866..1107
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 418..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1125..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1369..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1535..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 138..320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1562 AA; 173801 MW; FBA46CA2F92D1AD3 CRC64;
MWSARLLLFA SLFAPAALAF SRAPIPMAVV RRELSCESYP IELRCPGTDV IMIESANYGR
TDDKICDADP AQMENTRCYL PDAYKIMSQR CNNRTQCAVV AGLDVFPDPC PGTYKYLEVQ
YECVPYKVEQ KGSSVFLCPG LLRGVYQSEH LFESDHQSGA WCKDPLQASD KIYYMPWTPY
RTDTLTEYSS KEDFIAGRPT TTYKLPHRVD GTGFVVYDGA LFFNKERTRN IVKFDLRTRI
KSGEAIIGSA NYHDTSPYRW GGKSDIDLAV DENGLWVIYA TEQNNGRIVI SQLNPYTLRV
EGTWDTAYDK RSASNAFMIC GILYVVKSVY EDDDNEATGN KIDYIYNTEL SKDGFLDIPF
PNSYQYIAAV DYNPRDNLLY VWNNYHVVKY SLDFGALDSK PESSSSVIVF MDTTTTRTTT
RPSTVSTTTT TTSTTTTTRV SATTPVAQRP RPTSTTLPPL FPPADGNIPE GNTRTSPSSK
LPNVSVDYCN PMIMSDVSWP KMRQGLVARQ PCPTGTIGMA MYLCMGPEGY WDPQGPNLSN
CTSPWVNVIT QKLKAGETAA IIARELSEQT KSNLQAGDIT YTVKAMGQLV DLLDVQLRNL
TPGGKDSAAR SLNKLQKRER SCRIYVQAMV ETVNNLLQPQ AQSAWRDLST REQLRAATML
LDTVEQGAFI LADNLLKTDI VQENTNNIQL EVARMSTEGN LPDLKFPQSG QGNSITLSAS
TLKQHGRNGE IRMAFVLYKH IGAYLSTENA SMKLGREAMA TNYSVIVNSP VITAAINKES
NKVYLSEPVI FTLKHLQQSK ESFNPNCSFW SYSKRTMTGY WSTQDCRLLG TNRTHTTCSC
THLTNFAVLM AHVEVKNTDP VHDMLLDVIT WVGILLSLVC LLISLFTFCF FRGLQSDRNT
IHKNLCISLF IAESLFLVGI NRADQPIACA VFAALLHFFF LAAFTWMFLE GVQLYIMLVE
VFESEHSRKR YFYLVGYGVP ALVVAVSAAV DYRSYGTDRV CWLRLDTYFI WSFIGPATLI
IMLNVIFLGI ALYKMFHHTA ILKPDSGCLD NIKSWVIGAI ALLCLLGLTW AFGLMYVNES
TVIMAYLFTI FNSLQGMFIF IFHCVLQKKV RKEYGKCLRT HCCSGKSVES SIGSGKSSAS
RPPGRYSTGS QSRIRRMWND TVRKQSESSF ITGDINSSAS LNRGAMANHL ITNALLRPHG
TNNPYNTLFG ESAVYNNPSV GMYNMQEGIL NNARDTSVMD TLPLNGNHGN SYSIASAEYM
SDCVQIIDRG YNHKETTLEK KILKELTSNY IPSYLNNHEQ NRNLMNKLVN NVSNGGKDVG
LGGMGMGVGM GGMGMNVALG LDDQSSFPPH LHDEGLGLEL IREESNAPLL PQRPPLLPPV
DNLHHNHLHN QGLPHQPPLP HHHHPAFSSA TTTSSSSRRR IPQENSESFF PLLTNENTQD
VEPTSPSSHP HHLQHHRDSL YTSMPVLAGL PDTTANGTTT APLADKDAGE GLPAGGKSPE
ASQDDVYYKS MPNLGSRNHL HQLHSYYQLG RGSSDGFIVP PNKEDLPPEE ALQEPSHLIT
SL
//
