ID A0A1S3N9G3_SALSA Unreviewed; 325 AA.
AC A0A1S3N9G3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Tumor necrosis factor ligand superfamily member 10-like isoform X2 {ECO:0000313|RefSeq:XP_014012074.1};
GN Name=LOC106578044 {ECO:0000313|RefSeq:XP_014012074.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014012074.1};
RN [1] {ECO:0000313|RefSeq:XP_014012074.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014012074.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR RefSeq; XP_014012074.1; XM_014156599.1.
DR AlphaFoldDB; A0A1S3N9G3; -.
DR PaxDb; 8030-ENSSSAP00000089793; -.
DR GeneID; 106578044; -.
DR OrthoDB; 5348190at2759; -.
DR Proteomes; UP000087266; Chromosome ssa18.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR017355; TNF_ligand_10/11.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF28; TNF_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF038013; TNF10_TNF11; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR038013-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|PIRSR:PIRSR038013-50}.
FT TRANSMEM 46..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 164..323
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT BINDING 273
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared between all trimeric partners"
FT /evidence="ECO:0000256|PIRSR:PIRSR038013-50"
SQ SEQUENCE 325 AA; 36151 MW; B4714A21176B318F CRC64;
MATPNSLQQQ QQDYFRSVSS ESTTYMMVPA TAAAANTRRD AAPSKMWVAM VVIVVVVLQI
ASTTGLFVYL NMSISQVRSQ GVTEELKCLS LLNALDKDQD IPEDLAQLFG EPCIKLAEGI
KAYISKVTEN IISKQTFQEA RTLPRTFNTS GSKFATSVTQ RPSAHLTLRD SSAQGSPLYP
TPQPDLHQSC RHAVRSWANQ SFGAHLHNMT LANGRLRVPQ DGRYYLYSQV YFRYPSLTEG
DQHTTSHQLV QCVYKKTSYL RPIQLLKGVG TKCWAPDAEY ALHSVYQGGL FELRAGDELF
VSVSSPSMVH AEESSSYFGA FRLDL
//
