ID A0A1S3NAZ4_SALSA Unreviewed; 562 AA.
AC A0A1S3NAZ4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=phosphatidylinositol-3-phosphatase {ECO:0000256|ARBA:ARBA00013038};
DE EC=3.1.3.64 {ECO:0000256|ARBA:ARBA00013038};
DE AltName: Full=Phosphatidylinositol-3-phosphate phosphatase {ECO:0000256|ARBA:ARBA00031219};
GN Name=mtmr6 {ECO:0000313|RefSeq:XP_014012643.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014012643.1};
RN [1] {ECO:0000313|RefSeq:XP_014012643.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014012643.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR RefSeq; XP_014012643.1; XM_014157168.1.
DR AlphaFoldDB; A0A1S3NAZ4; -.
DR OrthoDB; 5474662at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF34; MYOTUBULARIN-RELATED PROTEIN 6; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 128..504
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT ACT_SITE 340
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 277..278
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 340..346
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 562 AA; 64792 MW; D5712B5C16B49196 CRC64;
MEHIRTPKVE QVRLLERFSN KSTSGTLHLT ATHLIFVESN NAATTAAQEI WILHHHIASV
EKLSLTTSGC PLVIQCRNFR VVHFVVQRER DCHDIYSSLL RLLRPVSYDE LYAFSYNPKQ
NEQQREEGWQ LIDLGAEFER MGVPCDRWQL TDVNRDYKIC ETYPRDLYVP ITASKPIIVG
SSKFRSKGRF PVLTYFYQEK KAAVCRCSQP LSGFSARCLE DESMLQAISK ANHNSRFVYV
MDTRPKLNAM ANRAAGKGYE NEDNYSNIRF QFVGIENIHV MRTSLQKLLE VVGSRFLSVN
DYLLGLESCG WLRHVKAVVD AAIFLTKAVT VEGASVLVHC SDGWDRTAQV CSLGALLMDP
YYRTIKGFMV LIEKDWISFG HKFADRCDQL DGDPKEVSPV FTQFLECVWQ LTEQFPQAFE
FSEWLLLQIH EHVHSCQYGN FLANNQRRRE ELQLGDRTHS LWAFLLSEQQ NYLNPAYCPA
YADTHPVLEP STLPCHFKFW RNMYHQFDRS MHPRQSVLKN VLTLKESNCQ LEDTIKELEA
DNAVIVSGLC VRLGWSSLWG CL
//
