ID A0A1S3NBC1_SALSA Unreviewed; 805 AA.
AC A0A1S3NBC1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Short transient receptor potential channel 1 {ECO:0000256|ARBA:ARBA00013302};
GN Name=trpc1 {ECO:0000313|RefSeq:XP_014012758.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014012758.1};
RN [1] {ECO:0000313|RefSeq:XP_014012758.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC permeant cation channel. Probably is operated by a phosphatidylinositol
CC second messenger system activated by receptor tyrosine kinases or G-
CC protein coupled receptors. Seems to be also activated by intracellular
CC calcium store depletion. {ECO:0000256|ARBA:ARBA00003698}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. TRPC1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009944}.
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DR RefSeq; XP_014012758.1; XM_014157283.1.
DR AlphaFoldDB; A0A1S3NBC1; -.
DR STRING; 8030.ENSSSAP00000114528; -.
DR PaxDb; 8030-ENSSSAP00000114528; -.
DR Ensembl; ENSSSAT00000222161; ENSSSAP00000170082; ENSSSAG00000079482.
DR GeneID; 106578467; -.
DR KEGG; sasa:106578467; -.
DR CTD; 7220; -.
DR OMA; SRPTIVX; -.
DR OrthoDB; 5406916at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR Bgee; ENSSSAG00000079482; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005457; TRPC1_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF56; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01642; TRPCHANNEL1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|RefSeq:XP_014012758.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 200..262
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
SQ SEQUENCE 805 AA; 92820 MW; ACFB6B817E2F4334 CRC64;
MVKWSLAPSS GMHISVLPYS FSVAMAALYQ VTDVSSPDKF LALKDVREVK EETTLDEKLF
LLACEKGDYY MVKRLLEEKT ELNINCVDVL GRDAVTISIE NQNLDILKLL LEHGCQATDA
LLVAIDSEVV GAVDILLNHR PRRSSKPSIA KLMQRIQNPE YSTTMDVAPV ILAAHRNNYE
ILTMLLKQDI SLPRPHAVGC ECTLCNAKNK KDSLRHSRFR LDIYRCLASP SLIMLTEEDP
ILRAFELSAD LRELSLVEVE FRNDYEELAK QCKMFAKDLL AQARNSRELE VILNHMANED
TVDKRGLMEE RMNLSRLKLA IKYNQKEFVA QSNCQQFLNT VWFGETASYR RKHTCLKMST
VLSVAVLWPL LSLCYLVVPR SRVGHIIHTP FVKFIIHSAS YFTFLLLINL YSLVYNEGKK
NTMGPALEMI DYLLILWIIG MVWSDVKRLW YEGLEDFLDE SRNQLSFVMN SLYLSTFALK
IVAHSKFKNV EDTERKNWDA FHPILVAEGL FAFANVLSYL RLFFMYTTSS ILGPLQISVG
QMLQEFGKFL GLFLLVLISF TIGLTQLYGK DQKDPAKSPA KDCEGIFCQQ QSNDAFHTFM
GTCYALFWYI FSLAHVALFV TRINYTEELR SFVGALIVGT YNIVVVIVLT KLLVAMLHKS
FRQIANHEDK EWKFARAKLW LSYFDDKCTL PPPFNILPSP KTVCYLLTSM SKWICSHTST
GKVKRQNSLK EWRNLKRKRD ENYQKIMCCL VHRYLTSTRQ KMQSTDQATV ENLNDLRQDL
SKFRNEMRDL LGFRTSKYAM FYPRS
//
