ID A0A1S3NE97_SALSA Unreviewed; 420 AA.
AC A0A1S3NE97;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=AMSH-like protease isoform X2 {ECO:0000313|RefSeq:XP_014013764.1};
GN Name=LOC106578960 {ECO:0000313|RefSeq:XP_014013764.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014013764.1};
RN [1] {ECO:0000313|RefSeq:XP_014013764.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014013764.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
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DR RefSeq; XP_014013764.1; XM_014158289.1.
DR AlphaFoldDB; A0A1S3NE97; -.
DR STRING; 8030.ENSSSAP00000113185; -.
DR PaxDb; 8030-ENSSSAP00000113185; -.
DR Ensembl; ENSSSAT00000148222; ENSSSAP00000113185; ENSSSAG00000115451.
DR GeneID; 106578960; -.
DR OMA; THNELTI; -.
DR OrthoDB; 5490729at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR Bgee; ENSSSAG00000079011; Expressed in head kidney and 14 other cell types or tissues.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR015063; USP8_dimer.
DR PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR PANTHER; PTHR12947:SF7; AMSH-LIKE PROTEASE; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|RefSeq:XP_014013764.1};
KW Protease {ECO:0000313|RefSeq:XP_014013764.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 253..381
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 202..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 47714 MW; 5AA34E2FB12489D1 CRC64;
MEQGFSFSTL KKLAAEPDHT DVSLTAAERV LALSKMGCSV EINEEITPRR YFRSGVEMER
MAAVYLEEGS LENAYVLYNK FITLFVEKLP SHRDYRECSV PEKQVIMKKL QDVAFPRKDQ
LRKLLHEKFN KEHAAYLMSQ SQAVVVDGCG QQLQRTSLVE QERLRVAQLR RMQMEAEQFR
YFEDQLRRQE LANRRDEAVA KVPEQTDGSC LSHSSKNHVR LDPNRNQPCL PSSKPAATLA
GVHTQLVEGL RRVVIPRDLT YKFLLLADSN TARGIETCGV LCGKLTQNEF LLTHVVVPKQ
SAGPDYCDME NVEELFSFQD HHSLLTLGWI HTHPTQTAFL SSVDLHTHGS YQLMLPEAIA
IVCSPKHNDT GVFRLTSSGM GEVARCRLKG FHPHSKDPPL FSICRHVVIK DLKTTVLDLR
//
