ID A0A1S3NEA4_SALSA Unreviewed; 946 AA.
AC A0A1S3NEA4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=unc5b {ECO:0000313|RefSeq:XP_014013465.1,
GN ECO:0000313|RefSeq:XP_014013466.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014013466.1};
RN [1] {ECO:0000313|RefSeq:XP_014013465.1, ECO:0000313|RefSeq:XP_014013466.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014013465.1,
RC ECO:0000313|RefSeq:XP_014013466.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR RefSeq; XP_014013465.1; XM_014157990.1.
DR RefSeq; XP_014013466.1; XM_014157991.1.
DR STRING; 8030.ENSSSAP00000055039; -.
DR PaxDb; 8030-ENSSSAP00000055039; -.
DR Ensembl; ENSSSAT00000084589; ENSSSAP00000055039; ENSSSAG00000042765.
DR KEGG; sasa:106578815; -.
DR OMA; ASSDWIY; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR Bgee; ENSSSAG00000042765; Expressed in semen and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF6; NETRIN RECEPTOR UNC5B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 31..946
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5010814059"
FT TRANSMEM 380..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 165..246
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 541..677
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 878..937
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 946 AA; 104240 MW; DEDCF1FA61A9BE1D CRC64;
MLSVRMQRDQ GLGPLLVLLV LTSGYLVSDA ESSDYSDVIP DSFSFASAEP LPEFQLEPED
GFIVKNRPVQ LRCRAAPATQ IYFKCNGEWV NQNDHVTRES LDQITGLVVR EVDISVSRTQ
VEELFGLEDY WCQCVAWSSA GTTKSSRAYV RIAYLRKTFE QEPLGREVRL EQEVLLQCRP
PEGMPPAEVD WLKNEETIDP SQDSNFLMTV ENDLIIKQAR LSDTANYTCV ARNQVAKRRS
STATLIVYVS GGWSSWTEWS QCNAQCGRGW QRRTRSCTNP APLNGGAFCE GSAFQRVTCT
TLCPVDGGWT DWAKWSACGT ECTHWRSRDC QAPPPRNGGQ HCSGSMMESK NCTDGLCTRN
KKVSIEHASY PLDPGMGVTV YAGLVGALLL CVVLVLCVGV LAYRRNCRHL HGDITDSSSA
LTTAFQPGNY KPPRQDNPHL LHPSAPPDLT ATACTFRDPL FSLQQGADDG HHKIPMTTSP
LLDPLPSLKI KVYNSSNLPS LELPAEGHSD PEILSLKHVG MGVTMVRDRD GHHTLSREPG
HSTSVTLGNL GGRLTIPNTG VSLLVPSGTI PQGKFYEIYL TINKWEKTTL PSEGSQTVLS
PVVSCGPSGM LLSRPVVLTL PHCAQLDTPT PDWSLTLKTQ THQGAWEEVL TVGEESLSSP
CYLQLEESNC HVVMEQLGTY GLVGQSCPPQ PACKRLQLAL FAPRAPCLSL DYILRIYCTQ
DTPHALKEVL ELERSLGGVL LEDPKPLLFK DSYHNLRLSI HDIPHSHWRS KLLAKYQEIP
FYHIWSGGQR PLHCTFNLER GSLAVSQLTC KICVRQVEGE GQIFQLHTDI QETLPPCSPL
PSGGTCLPSS QVGPYAFRLP TSIRQKICAS LDAPSARGCD WRLLAHSLGF DRYLNYFATK
PSPTGVLLDL WEASHQGDAD LVSLATALEE MGKSEVLVVM ATDGDC
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