ID A0A1S3NFC6_SALSA Unreviewed; 1611 AA.
AC A0A1S3NFC6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Rho GTPase-activating protein 23-like isoform X5 {ECO:0000313|RefSeq:XP_014014154.1};
GN Name=LOC106579110 {ECO:0000313|RefSeq:XP_014014154.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014014154.1};
RN [1] {ECO:0000313|RefSeq:XP_014014154.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014014154.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014014154.1; XM_014158679.1.
DR GeneID; 106579110; -.
DR CTD; 562244; -.
DR OrthoDB; 2997116at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 36..147
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 831..950
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1034..1225
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1239..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1311..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1403
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1449..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1558..1588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1611 AA; 175914 MW; 126BD2DFEBDBBDCD CRC64;
MAQAKGRNDG VMSSNENTRS LSSGEVEGVA WQGPRTVLLQ KNSQGFGFTL RHFIVYPPES
SLHNNLKDEE NGNGNGKGCQ RGRLEPMDTI FVKSVREKSP AHQAGLCTGD RLIKVNGESV
LGKTYSQVIA LIQNSENVLE LCIMPKDEDV LQLVSAYSQD AYLRGNEPYT GGAQHIPDPP
PLCYPRAKPA STAPLPPNHQ SPLDNWHCRP SPVNLASPLD NCSAAVNLTQ TSGRPRGSGE
NEEDVGGHFG SSAGQEGDWR PSLGQNRGRS SSAVSALDFH FANHNAAIAS ATLPHMPARK
GSLPATRAHS DAMCHQALSD WYYSQAEAAE RMSPRHRSIS QDRLAELGLG LALGPGGAGG
PGSNSMSSMA HRDHGVSQET LLLHHQAAAA SHDSYWLGGW GGVSGPGSRS CSESLLAAYA
SYERNYGRSQ ETLAQAAALV SPHCERAPAW PSQGAKEQDK DLGNHHTVTA TTAATLATAP
SVGRQIQQQQ VAEPQTQSRR LEEEELVGYK SYSPSFCRKA GHLLQQAHSF REPTYIGPHL
NWAPSAKTSP SDCEGGWIGG GMVVPRPSST PAVIPSSSED ERVRLGEERG ESRETLSPLP
LGQEVVLRQK PPMGRRTPVH ALRHPLYALP VDSAEPPVGL LPSPNTPTAG TPSPVCGGTR
MGDSLRRPNG SLQPHHSTPD SLASIPFIDD PISPSADLRA RHVPACSVVS SSSAPCPLVS
SLPCALTSST TTVSPVTLSS STSPLVKLRS QDSSSIKSRR SSYLLAITTE RSKSCDEGLN
TFREEGRVFS RLPKRVKSFF TDGSLESLRA AEEARSKRHS TSELGTITFS DVRKDGWLHY
KQILTEKGKK VGGGMRPWKR VFSVLRSHCL LLYKDKREAV LHGAGAGPGH GEDEHPPISI
RGCLIDIAYS ETKRKHALRL TTQDFCEYLL QAEDRDDMLG WIRVIRENSK TDNEELGFSR
QALISKKLND YRKHTTTGNK PDTSPRAHRM MPPFLLAKTD NAFINRSSSK DESKGPWGII
MKKAKKTGPK VFGVRLEDCQ PAVNNKFVPL IVELCCGLVE SMGLEYTGVY RVPGNNAMVS
NLQEQLNKGL EINITEERWQ DLNVISSLLK SFFRKLPEPL FTDDKYNDFI DANRLEDSGN
RLKSMKKLIH DLPDHYHHTL KFLVCHLKTV ADHADKNKME PRNLALVFGP TLVRTSEDNM
TDMVTHMPDR YKIIETLILH HDWFFSDGEV DKDEKAPVDI KRDMQPVPNI DHLLSNIGRT
GVPGSEASDS TTSDSPKDKS TWGSKKDLSA RDFLPLSIIS AVTRKRKIRP ISRPLSSSTD
EDSEHEPIKA SNYGVGGGAK EDEEEGVGKG CTPNGTEKVE EKGDEKCRKR IEAKQQSDRG
REKEGEGKKE GSAWAKDKEG VASPKPHPNS FLYTHYQPTT TSPSPPVEPS VSPHSKLPGL
ARGRSAVPSW LSPSRQPGPS QLYNTQKTQQ PQLEQQPLPV QYRKTRGGRA RPQSMNLDMV
IGKGEGEGGV GRRGDRVKVV RATTEVQRHR SSSVGVPQGC VVASLKVQRS SRLASALAPS
PVSSLSPPLP SSSFSPSWTD QGSLGSTVVM RRSALEPRDK RKAWRRHTVV V
//
