ID A0A1S3NG10_SALSA Unreviewed; 1909 AA.
AC A0A1S3NG10;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=scn4a {ECO:0000313|RefSeq:XP_014014172.1,
GN ECO:0000313|RefSeq:XP_014014173.1, ECO:0000313|RefSeq:XP_014014174.1,
GN ECO:0000313|RefSeq:XP_014014175.1, ECO:0000313|RefSeq:XP_014014176.1,
GN ECO:0000313|RefSeq:XP_014014177.1, ECO:0000313|RefSeq:XP_014014178.1,
GN ECO:0000313|RefSeq:XP_014014180.1, ECO:0000313|RefSeq:XP_014014181.1,
GN ECO:0000313|RefSeq:XP_014014182.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014014180.1};
RN [1] {ECO:0000313|RefSeq:XP_014014172.1, ECO:0000313|RefSeq:XP_014014173.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014014172.1,
RC ECO:0000313|RefSeq:XP_014014173.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC Nav1.4/SCN4A subfamily. {ECO:0000256|ARBA:ARBA00038083}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014014172.1; XM_014158697.1.
DR RefSeq; XP_014014173.1; XM_014158698.1.
DR RefSeq; XP_014014174.1; XM_014158699.1.
DR RefSeq; XP_014014175.1; XM_014158700.1.
DR RefSeq; XP_014014176.1; XM_014158701.1.
DR RefSeq; XP_014014177.1; XM_014158702.1.
DR RefSeq; XP_014014178.1; XM_014158703.1.
DR RefSeq; XP_014014180.1; XM_014158705.1.
DR RefSeq; XP_014014181.1; XM_014158706.1.
DR RefSeq; XP_014014182.1; XM_014158707.1.
DR STRING; 8030.ENSSSAP00000079274; -.
DR PaxDb; 8030-ENSSSAP00000079274; -.
DR GeneID; 106579124; -.
DR KEGG; sasa:106579124; -.
DR CTD; 572442; -.
DR OMA; RWPILMN; -.
DR OrthoDB; 1110761at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR Bgee; ENSSSAG00000063232; Expressed in ovary and 5 other cell types or tissues.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF223; SODIUM CHANNEL PROTEIN TYPE 4 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132,
KW ECO:0000313|RefSeq:XP_014014172.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 121..144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 220..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 397..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 587..611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 623..644
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 664..685
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 706..734
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 796..819
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1033..1051
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1072..1088
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1149..1175
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1274..1297
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1355..1373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1385..1403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1415..1435
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1472..1500
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1576..1599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 124..430
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 595..825
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 832..1027
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1032..1306
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1354..1609
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 923..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1809..1830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1848..1881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 421..455
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 927..941
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..992
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1856..1870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1909 AA; 215577 MW; 661CC938F96D7323 CRC64;
MAPLLPPTGA DAFRRFTPES LAEIERLMEE KRIAAEVEGY VDDGPSEPSK DLEAGKSLPM
IFGDAPTAML NTPLEDIDPF YKAKKTFIVI TKGNTIFRFN AESACYILSP FNHLRRGAIK
ILIHSLFSMF IMITILSNCF FMTMSDPPSW SKTVEYVFTG IYTFEASCKV LSRGFVVGPF
TFLRDPWNWL DFMVISMAYV TEFVDLGNVS ALRTFRVLRA LKTITVIPGL KTIVGALVQS
VKKMVDVMIL TVFALAVFAL IGLQLFMGNL RNKCVRWPIL NSTVFDDYNS TSSLDGTMGF
GETSNSTIPF DFKDYISNIE NHYYLEGSLD ALLCGNSSDA GKCPEGFTCI KAGRNPNYGY
TSYDSFGWAF LSLFRLMTQD YWENLFQLTL RAAGKTYMIF FVLVIFLGSF YLINLILAVV
AMAYDEQNEA TLKEAQDMEE EFQRLLEQYR IQAQEQADAA AGSQVTLTSR KELSHHSGSY
GGSADDEQSL GDDVIKDCNG RIVPRLAIVP VSSESESVPE DEFKEDSMLH LEQPGLKNRS
ASAVSVLTTV MEELEDAQKP CPPGWYKFAD TFLKWDCCVP WVWLKKWLLF IVMDPFVDLG
ITICIVLNTL FMAMEHYPMS PEFDHMLSVG NLVFTGIFTA EMVFKLCAMD PYYYFQVGWN
IFDSIIVTFS LVELGLANVQ GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL
TLVLAIIVFI FAVVGMQLFG KSYKECVCKI ATDCELPRWH MHDFFHSFLI VFRILCGEWI
ETMWDCMEVA GAGMCLVVFM MVMVIGNLVV LNLFLALLLS SFSGDNLSSD DDGEMNNLQI
AIGRINWGID WVKSFVRHMV LQLLGKKATG DKEGGEGIEG NPEKETFALN HLDTCQDSKM
ADGMTNCVDG LQADGEMSLN VPIAQGEPDF EDDDDDDSGS FTSDEENGHG DHIKLFGAVG
DESSVCSTVD YVPEPEPVEE EEEEEPEPEE PEACFTDGCI ARWPCLTFDV SQGRGKKWWN
LRRTCFTIVE HDYFETFIVF MILLSSGALA FEDIYIERRR TIKIILEYAD KVFTYVFIIE
MLLKWVAYGF KTYFTNAWCW LDFLIVDVSL VTLGANWMGY SELGPIKSLR TLRALRPLRA
LSRFEGMRVV VNALVGAIPS IFNVLLVCLI FWLIFSIMGV NLFAGKFYRC INTTTEELFP
ITEVNNRSDC LALQHATQEA RWINVKVNYD NVGLGYLSLL QVATFKGWMD IMYAAVDSRE
VEEQPSYEIN LYMYIYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKFGDD IFMTEEQKKY
HEAMKKLGSK KPVKPIPRPT NMIQGAVFDF ITQQFFDIFI MVLICLNMVT MMVETDDQSA
EKENVLYKIN LAFIVVFTGE CLLKMFALRH YFFTIGWNIF DFVVVILSVA GIMLSDIIEK
YFVSPTLFRV IRLARIGRVL RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLIMFIFSIF
GMSNFAYVKK QAGIDDIFNF QTFGSSIICL FEITTSAGWD GLLLPILNSG PPDCDPDIEN
PGSDVRGNCG NPGMGIMFFC SYIIMSFLVV VNMYIAIILE NFNTAQEESG DLLCEDDFVM
FDETWEKFDL EGTQFIEYAK LSEFCDTLQE PLRIAKPNRI KLISMDLPLV TGDKIHCLDI
LLAVTQEVLG EGVEMTAMKV SIEAKFNMNN PTTDSYEPIT TTLRRKEEEA AAVIIQRAYR
KHLLKRSILH ASFMRRSKRQ IRREQNEEPP EREGLLVRKM NVLYGSDLDL AAEMELAGLR
AQPISVPLVS NRPSDLPKQT QTTRPEPGRP LLLVVPVEVT SEVVLRSAPV TSDPPLDLPE
QTQPSGSEPT GLEPTWPEPA GPNLLVVPVE VTPYLCSRES IDNLRESIV
//
