ID A0A1S3NJ34_SALSA Unreviewed; 1496 AA.
AC A0A1S3NJ34;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106579657 {ECO:0000313|RefSeq:XP_014015260.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014015260.1};
RN [1] {ECO:0000313|RefSeq:XP_014015260.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014015260.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_014015260.1; XM_014159785.1.
DR GeneID; 106579657; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000087266; Chromosome ssa19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 1.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14633; R-PTPc-M-1; 1.
DR CDD; cd14635; R-PTPc-M-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045911; R-PTP-mu_cat_rpt1.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF8; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_014015260.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1496
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010313828"
FT TRANSMEM 772..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..186
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 188..279
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 286..379
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 384..482
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 483..588
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 944..1198
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1115..1189
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1230..1492
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1406..1483
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1496 AA; 169294 MW; C8A33DE5460810B3 CRC64;
MERLLTCLIA AGSLFLTVRG EVFKGDCNFE RPYTACGYSQ GKDDHFDWEQ ANTKERPSPN
PWMPTGSAFM MVNTSGRSSG QKAQLLMPQL KENDTHCLIF QYYMAGQREG ANPGQLNIYI
KENNSPLGIP VWNASGPAYP TWRQVELAVS TFWPNFYQIV FEAVSTGQRG LLAIKGIILQ
GHQCMSTPHF LHIKGVEVNA RQTATFQCTV NGRPQDTHNL WLQGIGGRRA PMRETKPVNS
RRYTATFDVE NTTKGDSGRY RCIVHSDKGV GVSSYADLTV KQPPVPIAPP QLTAVGATYL
WIQLNANSIN GDGPIVEREV EYRTVAGSLI DNQPVDKTTH KIGHLDPDTE YEISVLLTRP
LDGGTGAPGP PLRAKTKCAD PMHGPQRLEV VDIKSKQITV RWEPFGYNVT RCHSYNLTVE
YRYQAGGKEE TREEVCYDTL SLTPQHTIRN LSPYTNVSVK LVLRNPEGIK ESMDVDVLTD
EDVPGAVPLQ SIQGSTYEEK IALRWREPVQ TYGIIKQYEI SYKALSSFDT EFDLTNQSGR
VFKFSNETFH MFVGLYPGST YSFTIRASTV KGFGTPIITQ FTTKISAPLM PGYDQETPLN
QTDSTVTVLL KPAQSRGAPV SKYQVVVVEE ERPRRARRAV EILRCYPVPI HFQNTTVLNS
QYYFTAELPM GDIKTPVPFC IGDNRTYNGY WNAPLLPHKS YSVYYQAVST ANGETKIDCV
RVATKAAIIV TQLTTPYIRI APAAGDNQLT GAATRKPDAV EPEKQTDHTV KIAGVIAGIL
LFVIIFLGVV LVMKKRRTYH SYTYYLKLAK KRKETLSSTR QEMTVMVNSM DKSYTEQGTN
CDEAISFMDT HSHTLNGRTA SPLSFTMKTN SISTSVPTSY YPDENHTMTS DTSSLVQSHS
HSYKKKREVA DVPPYQTGQL HPAIRVADLL QHITQMKCAE GYGFKEEYES FFEGQSAPWD
SAKKDENRMK NRYGNIIAYD HSRVRLQAIE GEQSSDYINA NYVDGYHRPN HYISTQGPMQ
ETVYDFWRMV WQENTATIVM VTNLVEVGRV KCCKYWPDDT EIYRDMKVTL IETQLLSEYV
IRTFAVEKRG AHEIREIRQF HFTGWPDHGV PYHTTGLLGF VRRVKSKTPA NAGPMVVHCS
AGAGRTGCFI VIDIMLDMAE REGVVDIYNC VRELRSRRVN MVQTEEQYVF IHDAILEACL
CGDTTVPANQ LRSVYYDMNR LDPQTNSSQI KEEFRTLNMV TPTLRVEDCS IALLPRNHEK
NRCMDVLPPD RCLPFLITID GESSNYINAA LMDSYKQPSA FIVTQHPLPN TVKDFWRLAL
DYHCTSIVML NDVDPAQLCP QYWPENGVHR HGPIQVEFVS ADLEEDIISR IFRIYNAARP
QDGYRMVQQF QFLGWPMYRD TPVSKRSFLK LIRQVDKWQE EYDGGEGRTV VHCLNGGGRS
GTFGAISIVC EMLRHQRSVD VFHAVKTLRN NKPNMVDLLD QYKFCYEVAL EYLNSG
//