ID A0A1S3NK35_SALSA Unreviewed; 2453 AA.
AC A0A1S3NK35;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nuclear receptor corepressor 2 isoform X1 {ECO:0000313|RefSeq:XP_014015779.1};
GN Name=ncor2 {ECO:0000313|RefSeq:XP_014015779.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014015779.1};
RN [1] {ECO:0000313|RefSeq:XP_014015779.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014015779.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR RefSeq; XP_014015779.1; XM_014160304.1.
DR GeneID; 106579918; -.
DR KEGG; sasa:106579918; -.
DR OrthoDB; 5482374at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Receptor {ECO:0000313|RefSeq:XP_014015779.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 427..478
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 606..657
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 609..653
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 610..657
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 47..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1721..2006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2060..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2126..2216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2295..2453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..714
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1741..1764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1835..1902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1910..1924
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1928..1964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1981..2006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2126..2143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2189..2216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2254..2268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2362..2379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2386..2429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2453 AA; 271280 MW; 6487E08DE7B42F68 CRC64;
MSSHPQSVPQ GRRAVDIRHL PNPASLPLQL ARAHTDVGLV DYHPHSRDYS SHLAQPHRRR
PSLLSEFQPG NERGQEQHIR YEHIYLPDPN NLSEVEYAEM KRPRLDMGPE SLMRHSAHRP
QLPLGGAEDM SKDRGSSMGK LEPISPVSPA QMDPDLDLVP ARFSKEELIQ NMDRVDREIT
MVEQQICKLR KKQVQQQLEE EAAKPQEPER SMISPPPSEA KHRSLVQIIY DENRKKAEEA
HWILEGLGPR VELPLYNQPS DTKQYHENIK INQAMRKKLI LYFKRRNHAR KQWEQKFCQR
YDQLMEAWEK KVDRIENNPR RRAKESKVRE YYEKQFPEIR KQRELQERMQ SSRVGQRGGG
LASSSARSEH EVSEIIDGIS EQENTEKQMR QLAVIPPMLF DAEQQRIKFI NMNGLMDDPM
KVYKDRQVMN MWSEQEKDTF REKFIQHPKN FGLIASFLER KTVAESVLFY YLTKKNENYK
NIVRRNYRRR GRSQHSQQQQ QQLQVNRSSQ EDKEEKEKEK EKEKEKEKEG ERDEEKTEGE
DKEDVMKDDT SGEDGEDKEP TVAFKGRRTA NSQGRRKGRV TRSMTSEVEE TATPPLSSEL
ANLEMNESSR WTEEEMETAK KGLLQYGRNW SAIAKMVGSK TVSQCKNFYF NYKKRQKLDE
ILQQHKMKSE RERKARRKGK ALQSEEASAP SAAEEEEMEG SGASGNEEEA PEDGEGGANN
SSDTESLPSP RSSEDSKAKE EGGGRAKAGS KPGDKEASGS HMVQGGDEKP PGDGDKAIKQ
EVKTEAGEGS KELPSESTDS DRKPPTAEAE ESKSSSKSSK RDHEPKTGSH ADSDSSATCS
ADEVEESENT EKNRMTSPNR PSLLNYAHDG VISSPLQKPM DLKQLKQRAA AIPPIMPQIP
EGGPRGGVGK AVLPPHALAL YQQQITMAHG ESSQEAKLQQ HAGQPSKQHP YPAQGDRDPH
NISSPRVRPR SPSTSDKDEL EGNERWLQTL LHGLHKSRAF SPHGDPKKQA VGPEDLRATT
LGRPVMSPYP MSPRDMAKLS HDQHLLHYNS SFQQVGLSGP PGLQQDGIRM AAVRPLHMPE
PPPLISSNKP GGSITQGTPV QLHSPAHGMD HGKMPPAQMG LSWMDQRKVG ESKCLEWVQH
SQPWFAGPYP VVKQEQLSPR CSSSQAENLS TQGAPHDANA GRGSIPAVQG GSITKGIPGT
RVHQDSPISY RGGSITQGTP ADVLYKGTIT RLITEDNPSR AERERDEALS KGHVVYEGIS
GHILTYDRLP SQNPKEDGRG QPGEILGLKR PYDVMEGGIS RGLPMRDSLS AANCEGLMGR
AMPHERDSPH PTHHIRGSIS QGIPRHLEPQ DGYMRREPKQ MKREGSPPRG PGQMADPMKG
RDGMVPTVKE GGRSIHLIPR EELRQMPEVM MMAKAGKDGI IAQGAPMKQE QGGLRKGHDV
RSIIASSPRS HYGMPSHLEM RGPEQRGRYE EGPKGRPSAV VSTASSMARS SPLAMGGDQG
GKAHQSPVRY EEPKGGMRAP YTGPSHRGSP LSRESGQRQH DGSNKNQPQE RKSTPTPREM
SSGKSPLPGV AEQQAQQQAQ QQASLASYER LLQGLGADVY RGQIPLAFDP AALRQGIPID
PAAYYLPRHL APNPGYPHPY PYLIRGFPDT AALENRQTLL NDYITSQQMH QWPAAAAMAA
QRSDLLRGLS PRDQPLQLPY SAAPRGIIDL SQVPHLPVLV PPSAGSSGSP MDRITYIPGA
FPSQPYTSSP ISPVGPQHMS KQHGTPSSAD RERERDRERD RERDREQERE RERDRERRDR
DRERERERDR DREKGISHGN VEHAPIWRPG TEHSSGGSVR PSSHSGYGHQ HSPVSPRTQD
SVQQRPSVLH NTGGKSLPVS DHNNPSVLRS MPGSNRYPGY GYQQSMDSKE MGRDGSKSRG
GLPKHTQDQH GPSISSSKSD PKLASPNQGG YPSPYPQGSS ASHHSGRPPP HLLPPQSDNA
AGRGESGTPS REKTQNKPMS VQEQELRSLG KTTMTAANFI NAIIMRQISC ETGMPETGSL
VANSASDVQQ KMMPMEQHGL YRPPSEERLS PGQQPQSPLV KSSQRVVTLA QHISEVITKD
YTRQTQQQVH MQQSYHNNSV LDLTRTTSAP QAPPASQEPS QGPRYTPEGA GGDRARDRSP
PQPKVSPVNM STDGIEPVSP AGAMSEPETQ GASYPNEQGM GSRSPPSTSQ PPAFFSKLTE
STSAIVKSKK QEMIKKMTVV GSDAEFNPGQ PGTEIFNMPA STTAGPVSIR SHPAPEVSGN
TIGLEAIIRK ALMGNYDDQA EERPPSSNAI NPMVASVPAA MLPADGRTED SYSLQGGGKP
KGSGRSNGRK AKSPGPGLSG GERPSSVSSV HSEGDANRRT PVTNRVWEDR PSSTGSTPFP
CNPLTMRFPS GMPVSNPSPT PSGQLGAQGQ GRSWEEEPKP LLCSQYETLS DSE
//
