ID A0A1S3NKR6_SALSA Unreviewed; 2434 AA.
AC A0A1S3NKR6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nuclear receptor corepressor 2 isoform X12 {ECO:0000313|RefSeq:XP_014015791.1};
GN Name=ncor2 {ECO:0000313|RefSeq:XP_014015791.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014015791.1};
RN [1] {ECO:0000313|RefSeq:XP_014015791.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014015791.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR RefSeq; XP_014015791.1; XM_014160316.1.
DR GeneID; 106579918; -.
DR OrthoDB; 5482374at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF21; NUCLEAR RECEPTOR COREPRESSOR 2; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Receptor {ECO:0000313|RefSeq:XP_014015791.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 427..478
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 606..657
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 609..653
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 610..657
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 47..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1028
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1156..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1324..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1689..1986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2041..2062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2107..2195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2225..2259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2276..2434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..714
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1548..1581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1722..1745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1816..1883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1891..1905
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1909..1945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..1986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2170..2195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2235..2249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2343..2360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2367..2410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2434 AA; 269346 MW; 5116A5C565E1B238 CRC64;
MSSHPQSVPQ GRRAVDIRHL PNPASLPLQL ARAHTDVGLV DYHPHSRDYS SHLAQPHRRR
PSLLSEFQPG NERGQEQHIR YEHIYLPDPN NLSEVEYAEM KRPRLDMGPE SLMRHSAHRP
QLPLGGAEDM SKDRGSSMGK LEPISPVSPA QMDPDLDLVP ARFSKEELIQ NMDRVDREIT
MVEQQICKLR KKQVQQQLEE EAAKPQEPER SMISPPPSEA KHRSLVQIIY DENRKKAEEA
HWILEGLGPR VELPLYNQPS DTKQYHENIK INQAMRKKLI LYFKRRNHAR KQWEQKFCQR
YDQLMEAWEK KVDRIENNPR RRAKESKVRE YYEKQFPEIR KQRELQERMQ SSRVGQRGGG
LASSSARSEH EVSEIIDGIS EQENTEKQMR QLAVIPPMLF DAEQQRIKFI NMNGLMDDPM
KVYKDRQVMN MWSEQEKDTF REKFIQHPKN FGLIASFLER KTVAESVLFY YLTKKNENYK
NIVRRNYRRR GRSQHSQQQQ QQLQVNRSSQ EDKEEKEKEK EKEKEKEKEG ERDEEKTEGE
DKEDVMKDDT SGEDGEDKEP TVAFKGRRTA NSQGRRKGRV TRSMTSEVEE TATPPLSSEL
ANLEMNESSR WTEEEMETAK KGLLQYGRNW SAIAKMVGSK TVSQCKNFYF NYKKRQKLDE
ILQQHKMKSE RERKARRKGK ALQSEEASAP SAAEEEEMEG SGASGNEEEA PEDGEGGANN
SSDTESLPSP RSSEDSKAKE EGGGRAKAGS KPGDKEASGS HMVQGGDEKP PGDGDKAIKQ
EVKTEAGEGS KELPSESTDS DRKPPTAEAE ESKSSSKSSK RDHEPKTGSH ADSDSSATCS
ADEVEESENT EKNRMTSPNR PSLLNYAHDG VISSPLQKPM DLKQLKQRAA AIPPIMPQIP
EGGPRGGVGK AVLPPHALAL YQQQITMAHG ESSQEAKLQQ HAGQPSKQHP YPAQGDRDPH
NISSPRVRPR SPSTSDKDEL EGNERWLQTL LHGLHKSRAF SPHGDPKKQA VGPEDLRATT
LGRPVMSPYP MSPRDMAKLS HDQHLLHYNS SFQQVGLSGP PGLQQDGIRM AAVRPLHMPE
PPPLISSNKP GGSITQGTPV QLHSPAHGMD HGKMPPAQMG LSWMDQRKVG ESKCLEWVQH
SQPWFAGPYP VVKQEQLSPR CSSSQAENLS TQGAPHDANA GRGSIPAVQG GSITKGIPGT
RVHQDSPISY RGGSITQGTP ADVLYKGTIT RLITEDNPSR AERERDEALS KGHVVYEGIS
GHILTYDRLP SQNPKEDGRG QPGEILGLKR PYDVMEGGIS RGLPMRDSLS AANCEGLMGR
AMPHERDSPH PTHHIRGSIS QGIPRHLEPQ DGYMRREPKQ MKREGSPPRG PGQMADPMKG
RDGMVPTVKE GGRSIHLIPR EELRQMPEVM MMAKAGKDGI IAQGAPMKQE QGGLRKGHDV
RSIIASSPRS HYGMPSHLEM RGPEQRGRYE EGPKGRPSAV VSTASSMARS SPLAMGGDQG
GKAHQSPVRY EEPKGGMRAP YTGPSHRGSP LSRESGQRQH DGSNKNQPQE RKSTPTPREM
SSGKSPLPGV AEQQAQQQAQ QQASLASYER LLQGLGADVY RGQIPLAFDP AALRQGIPID
PAAYYLPRHL APNPGYPHPY PYLIRGFPDT AALENRQTLL NDYITSQQMH QWPAAAAMAA
QRSDLLRGLS PRDQPLQLPY SAAPRGSSGS PMDRITYIPG AFPSQPYTSS PISPVGPQHM
SKQHGTPSSA DRERERDRER DRERDREQER ERERDRERRD RDRERERERD RDREKGISHG
NVEHAPIWRP GTEHSSGGSV RPSSHSGYGH QHSPVSPRTQ DSVQQRPSVL HNTGGKSLPV
SDHNNPSVLR SMPGSNRYPG YGYQQSMDSK EMGRDGSKSR GGLPKHTQDQ HGPSISSSKS
DPKLASPNQG GYPSPYPQGS SASHHSGRPP PHLLPPQSDN AAGRGESGTP SREKTQNKPM
SVQEQELRSL GKTTMTAANF INAIIMRQIS CETGMPETGS LVANSASDVQ QKMMPMEQHG
LYRPPSEERL SPGQQPQSPL VKSSQRVVTL AQHISEVITK DYTRQTQQQV HMQQSYHNNS
VLDLTRTTSA PQAPPASQEP SQGPRYTPEG AGGDRARDRS PPQPKVSPVN MSTDGIEPVS
PAGAMSEPET QGASYPNEQG MGSRSPPSTS QPPAFFSKLT ESTSAIVKSK KQEMIKKMTV
VGSDAEFNPG QPGTEIFNMP ASTTAGPVSI RSHPAPEVSG NTIGLEAIIR KALMGNYDDQ
AEERPPSSNA INPMVASVPA AMLPADGRTE DSYSLQGGGK PKGSGRSNGR KAKSPGPGLS
GGERPSSVSS VHSEGDANRR TPVTNRVWED RPSSTGSTPF PCNPLTMRFP SGMPVSNPSP
TPSGQLGAQG QGRSWEEEPK PLLCSQYETL SDSE
//
