ID A0A1S3NL13_SALSA Unreviewed; 1289 AA.
AC A0A1S3NL13;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Breakpoint cluster region protein-like isoform X2 {ECO:0000313|RefSeq:XP_014015891.1};
GN Name=LOC106579959 {ECO:0000313|RefSeq:XP_014015891.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014015891.1};
RN [1] {ECO:0000313|RefSeq:XP_014015891.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014015891.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; XP_014015891.1; XM_014160416.1.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 4.10.280.30; Bcr-Abl oncoprotein oligomerisation domain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR015123; Bcr-Abl_oncoprot_oligo.
DR InterPro; IPR036481; Bcr-Abl_oncoprot_oligo_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF3; BREAKPOINT CLUSTER REGION PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF09036; Bcr-Abl_Oligo; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF69036; Bcr-Abl oncoprotein oligomerization domain; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 518..710
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 727..884
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 911..1038
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1072..1266
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 86..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 28..55
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 343..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1289 AA; 145603 MW; 582AC59CD60CDD4F CRC64;
MVEPVGFVEA WKAQFPESNP PNMELKSLGD VEQELEKCKA SIRQLELEVN KERFRMIYLQ
TLLAKERKAY DGQRWGIKRM SLKNIGDQSS VSDTQRSHLD EPSVEEQPGE AVDAGSCKQY
PEEEVDGVSP SKQSGGFSPH RPTVGPPDTN LDRVGMGSVA ALRSNFEHIK RTNSHTAGDG
KGVGGTERPF YVNMEYHHER GLVKVNDREV SDKISSLGCQ AMQMERKRSL HSLPGNLSTA
TGEIRKSVLR GRSTEGGCGY NGLYDDAVEV NPHFFKDSVI RSNGGRQPTD CQPYTSVYVG
GMMGEGRIIH IRDHSVEEDS HLTWPRRSYS PGSFDDVGGG YTPDCSSNEN LTSSEEDFSS
GQSSHVSPSP TTYHMYRPKS RSPSQISQQS FDSSSPPTPL SQKRLKQQVL VSEASIVGVR
RTGQIWPDDG NSTTSSRTSH DNSLHGDLAP YSGTPPSYGY LEQTEEHQQH HDLQPFSTSP
SSSPHLRSKS RSSRDTHSSG SLEFTLSTEL DQEKELEMRK WVLSGILASE EMYLSHLGAI
LLPMKPLRAA ATTSQPMLTI QQIETIFFKV TELHEIHKDF YDALLPRVQE WSHNQCVGDL
FQKLASQLGV YRAFVDNYKV AVETADKCCQ ANVQFAEICE NLKVRSSKEC KDQAKNSLET
LLYKPVDRVT RSTLVLHDLL KHTPSSHPDY PLLQDALRIS QNFLSSINEE ITPRRQSMTV
KKGENRQLLR DCFMVELVEG SRKLRHVFLF TDLLLCAKLK KQTAGKSQQY DCKWYIPLSD
LTFQTIEDSE ATPIPQVQEE EIDAMKIRIS QIKNEIQREK RTTKGGKAIE RFKKKLLEQE
SLLLLMSPSM AFRVANRNGK GFTFLISSDY ERAEWREIIR EQQKKCFKSF SLTSLELQML
TNSCVKLQTV HNIPMTMNKE EDESSGLYGF LNVIVHSASG LKQSLNLYCT LEVDSFGYFV
NKAKTRVYRD STEPNWNEEF EIELEGSQTL RLLCYEKCYN KAKQNKEDGE NTDRIMAKGQ
IQLDPQTLQT KDWQRTVITM NGIEVKLSMK FTSREFSLKR MPSRKQSGVF GVKISVVTKR
ERSKVPLIVK QCVEEIERRG MEEVGIYRVS GVATDIQALK AAFDANNKDV SVMMSEMDVN
AIAGTLKLYF RELPEPLFTD DLYPNFAGGI ALSDSVAKES CMLHLLLSLP EPNLVTFLFL
LDHLKRIADN ESVNKMSFHN LATVFGPTLL RPSEKDSKIP ANATQPITMN DNWSLEVMSQ
VQVLLYFLQL QSIPTPDSKR QSILFSTEV
//
