ID A0A1S3NLS4_SALSA Unreviewed; 3265 AA.
AC A0A1S3NLS4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Vacuolar protein sorting-associated protein 13A-like isoform X1 {ECO:0000313|RefSeq:XP_014016185.1};
GN Name=LOC106580084 {ECO:0000313|RefSeq:XP_014016185.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014016185.1};
RN [1] {ECO:0000313|RefSeq:XP_014016185.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014016185.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR RefSeq; XP_014016185.1; XM_014160710.1.
DR KEGG; sasa:106580084; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF22; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..369
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 573..796
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1172..1269
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1997..2542
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2856..3033
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3038..3125
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3127..3240
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 800..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 93..128
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 805..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3265 AA; 366856 MW; 279F2206EDFCEBFA CRC64;
MVFESVVVDV LNRFLGDYVV NLDSSQLKLG IWGGDAVLRN LEIKENALSQ LDIPFKVRAG
HIGRLELKIP WKNLYTQSVE ATLDGVYLLI VPTASIKYDA EKEEKQLQEA RQRELQRIEE
TKQKAAEQDN PALEKQDTFV EKLVTQVIKN LQVKISNIHV RYEDDVTNPN CPFSFGVSLQ
NLSLQTADEN WMPCLLDEKA KLFFKLVQLD NLFAYWNVNS MLYSNHMPDE ALRCLQDSIP
GGSTPMNHDF IFRPITADAK LRMNPRSDVD FSSPKVDLVV NLREVAVELN RPQYISILEL
LGSVDMMSRN LPYRKYRPQV HVHTNAYLWW QYVITGIMEV DVKPRLHMWS WQHIRCHRQT
VKHYRELYKA KITSKKPTEK QLRELEEPER TLDIFNITLA RQQAEMEASK AGLRIFRPGV
KVEEEESQGW LGWMWSGWSG DGGAEAKEVK TGAFDELMTS AEKAKLYTAI GYSEIAVNHN
LPKNFEDMKI NFHMERMSVS MKDNKDQNEI LKLTVEDLKS MLTQRPGAQA IKLSAQLSLF
EVTGLANNRP APTLLSSRKA ATVTGTPLLD ILFETNPLDE SADQRLRVES QPLEIIYDAV
TVNSMSAFFS PPDDLQLDEL TNATLMKLEQ FRDRTSTGLM YVIETQKVLD LNVNLMASYV
IVPQTGFYDS TQNLMLLDLG HFKVSSLSRE GLPQLSVGRS TIEDIMSRAY DSFDVQLSSL
QFLYSKPDGD WKKARKLRQS ALHILEPVDV KVVFSRAMVV TDSRMPKFKI SGELPLLSLR
ISDDKVRGVL ELIDSIPLPE SRPAPRNTNA HSTSKALKQS YTPQLTPRKP TMAELRNSLI
WESGSEEDLF YDAPSSPIGD RPFFPDNMPS PLQRSDSVKR RGLVKKDPKK NMTEFLMTFE
ISKLSVQLCR LSGGEEVTVL HLDIEGLGTE LKLRTFDMTS YTFLREICLE CPEYMDSEEK
KVHLITTLDN TEEDLLTLEY TKADKNGPEF KSEYKNTEQS VKVNFSSLDI HLHTEALLNA
MNFLISLLPP TKEVAPSQEE LPTIPEEDEG EGEEGEKKEE SAVAKKTSSK KSKFEDVVNL
HIRADLNCLK VFIRGQSRRI AEIRIEGLVS EVLMRKKAVE VLANLKNIVI LDCDKEALYK
QCVSIADEEV FAFRMVNHTE ATEGDAYLDM GKVDTSITLT VGCIQVIFLN KFVSSILAFI
NNFQVAKEAL AEVTVQAAEK AATGVMELAE RSTRISLDVD FNAPVVFLPQ SSSSANVIVA
DLGMVTVKNR FAMVPSQMHV KIPPVMDTMT VGLSDLKMYR TTFEEGRFQG EIQLLKPVNL
DLSIQRNLSA SWYHSIPDIE ITAHLKPMNL ILGQDDMTVV LRTLSGNLSE TSDAASPPPP
PPPRTVDRSD TASTKGSQAS GGTGTNPTSG NTVVTAAVVE TQKSTKLKST LKLDFKFDSM
TLVLYSPNGT EVQVLDLRDE QLKLAEFTLG TISTSVHMFS DGSMKASVKL TDCLLDDKRC
RVKKITARMM AMRPDAERNV MVEVNYKQGR DGTSFDTVVQ DVYLCASMEF LLTVADIFLK
ASQQGFSSAT PKNSSSTKPT AAAASKESAP VVVAKSEINV LVKNPEIVFV ADLTRADAPA
LVMTTECELV MKSDPDGQLM TAVVKDLKVV ACPFLKEKRN KETTVLQPCQ VFFKSTQSST
SPQAMEVCIN ALTLKVSPII INTVITIQSV LSPAGAETPQ SELESPVPPD LWERRSWRDL
KLWFLEEEGK DEDAQSLVPL IPQGESLQLA INSICLTLEA GVGHRTVPML LAKSSFHGDV
KNWSTLINLH SQLNLEVHYF NEVMGVWEPL LEPLEDETRD GFRPWTLGLK MKKKPVKYTG
ISEDVDYSIP DYKTVISISS KDQLNITLSK CGLGMLSNLG TAFAEAAKQA SDSFQKDEAP
FVVKNRLGLT VSVVHSELFS PLGREVTARR VELQNGESLN MDYRRTTTHS DQFSAMTSLV
AKDYYIQPTP VGHTSTGMIP LIKVGRGMYS VMHKDSGVTR FLVCQIYSVE GSKYIKIRSP
FQIINHFSIP FRVMEGSTCL GISLPTEEFC VPLDSYRSEL RLQPVTEGDD QYDCSEGFSY
ELVSQQPGAR VQQTCHRHGD SAGVLMVNIV PLKDTVTSQH TGMAGEHFDE PYILHLWPSV
LLRNLLPYPI TYHLQDSEEP TPITLMDGHS AQLHTAIMDQ SSLELRLLDY LGQDWQAHYG
LCGDLDEITF IVFSSLRVEE EVVRLGEGGE GKRAELDIAV HVKYDAGQTE VAIHSPYWMV
NKTGRLLQYK ADDIHRKHAM DYDMPLLFSF KPHNFLQNNK VRLMISDSDL SDDFSLDTVG
SYGEVKCKGR LKDYVIGVKI DASSFSLTRI VSFVPYYLLV NRTKHVIWVG EEGQDDWTEA
RPQQAAIPFW PERDSKKLKV KVEGSRSTPQ TMDFTKPENC LLLHLDNTLG GVIVDVNLSD
HSIIIRFSDY HDGAAPFLII NHTQEQTVEF YQRFRRDSSE WVADELLGLS FSVEETQPSS
QKEKDKLSPG KAMYYTWAEP SGSRSLAWQC GSYSGELKSE EDLRLDVNEE GKLYLISFYE
GLQRVALFTE DRRIYKLLCE SEKAELAEQE IILSLQDVGI SLVNNSSRQE VSFIGITSSD
VVWESKPKKK SRWKPLSGKD AELLETHFKE YTESGPVDNA ILDLENNFQV SLTHNGQDMR
MMQPYDAPIR RSFLPGVKVE YSVSARQSAY RVQINRIQIQ NQLPGAIFPY VFYPIKLPKS
VTMDSEPKPL TDISIVTRAA GHSDISRIKY FKVLIQEMDL KLDLGFLYAV LDLFTPENAS
VMTSEQQVEL FEKDIEYLKT ELNDVSATDT SPISLYEYFH ISPIKLHLSF SLSSGGEDGN
KEKRETEIIP VQSLNLLLKS IGATLTDVQD VVFKLAYFQL TFQFRTRQQL QWEVIRHYSK
QAIKQMYVLV LGLDVLGNPF GLIRGLSEGV EAFFYEPYQG AIQGPEEFVE GMALGVKALV
GGAVGGIAGA ASRITGAMAK GVAAMTMDEE YQQKRREAMN KQPSGLREGL TRGGKGLVSG
FVSGITGIVT KPIKGAQKEG AAGFFKGVGK GLVGAVARPT GGIIDMASST FQGIKRAAET
SQDVESLRPP RFIHEDGVIR PYKEREGIGS QMLQKIENGR FAKYRYFAHA KVNESDFLMI
TKRGIFFVTK GTFGQLTCEW QYLFDEFTKE PMIVEGRRLR IEAKERVKSV FHAKEFGKII
NFRSPEIAKW VLTKLEDARE SLHKY
//