ID A0A1S3NLZ7_SALSA Unreviewed; 803 AA.
AC A0A1S3NLZ7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=ARF GTPase-activating protein GIT2 isoform X3 {ECO:0000313|RefSeq:XP_014016226.1};
GN Name=git2 {ECO:0000313|RefSeq:XP_014016226.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014016226.1};
RN [1] {ECO:0000313|RefSeq:XP_014016226.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014016226.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014016226.1; XM_014160751.1.
DR AlphaFoldDB; A0A1S3NLZ7; -.
DR OrthoDB; 2877020at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007420; P:brain development; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR047161; GIT-like.
DR InterPro; IPR032352; GIT1/2_CC.
DR InterPro; IPR022018; GIT1_C.
DR InterPro; IPR013724; GIT_SHD.
DR PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1.
DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF12205; GIT1_C; 2.
DR Pfam; PF16559; GIT_CC; 1.
DR Pfam; PF08518; GIT_SHD; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00555; GIT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 1..123
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 165..197
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 377..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 803 AA; 89213 MW; 28B8E9BB4B4BA20E CRC64;
MMSKRLRNSE VCADCSVPEP RWASVNRGVL ICDECCSVHR SLGRHSSQVR HLTHTPWAPT
QLQMVQTLYN NGANSIWEHC LLDPMMSGKR KANPQDKVHP NKTEFIKAKY QMLAFVHRMP
CRDDDSFTAK DLSKQLHSSV RTGNLETCLR LLSLGAQANF FDPEKGNTPL HVAAKAGQVS
QAELLTVYGA DPGAPDSNAK TPINYARQAG YHDLADRLVE IQYELTDRLA FYLCGRKPNH
KNGQHFIVPQ MADRNISLDL SELAKAAKKK LQSLSNHLFE ELAMDVFDEV DRRETDAVWL
ATQNHSTLVT ETTVVPFLPV NPEYSSTRNQ GRQKLARFNA HEFATLVIDI LSDSKRRQLG
NSTISPKENV ELILKSRSGG EGLDNDQPDY DSVASDEDTD KEPPSGKDRT KSLDSDLSDG
PVTVQEFLEV KNALSASEAK IQQLMKVNSN LSDELRLMQK KLRSLQSENT SLRRQGPTTH
IYQVPISSGS EYTDPSSSSP SAMKRRQSAR ASRPMSMSIY ETGSGLKPYL PKGDTPYPEE
GVPTLQPFLP PHTGRGAFVT SSSLPSFPST QSWSRDKSAL RASKLDKQSS MPDSDYDNTT
NDYEMKDSGR GRLRSSGWLG EGSSIPELDD LGAEPDPALP STEDVIRKTE QITKNIQELL
RAAQENKHDR PCEGVRRLRH SLGCFSTLVP WAEKAPSPVQ PLSLCSLDPA SRFIPCSERI
YVAVTEMAAL FPKRPHSEMV RGPLRLLTSS SFRLQGECRK ATPPEEGPGP DLQLVTQQVI
QCAYDIAKAA KQLVTITTKE NSN
//
