ID A0A1S3NNY3_SALSA Unreviewed; 1139 AA.
AC A0A1S3NNY3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=LOC106580514 {ECO:0000313|RefSeq:XP_014017148.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014017148.1};
RN [1] {ECO:0000313|RefSeq:XP_014017148.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014017148.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014017148.1; XM_014161673.1.
DR AlphaFoldDB; A0A1S3NNY3; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 563..586
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 606..628
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 715..733
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 753..770
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 801..820
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 841..865
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 901..920
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 927..946
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 978..1009
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 170..433
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 492..979
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1139 AA; 128550 MW; 5D5F56EA98784D5F CRC64;
MDHERMGDRG MGDRGMGDRG MGDRGMGDRA MGGIHHGYDE EEDQQNIYIG VPVPRGYRRK
RRRRRSAGGR EAADKERGDR HYDHHRHHDH DDRDRYRDLE EGLMDPHDLQ VPQDINRTMS
PAAERLRYIL GEDDDMPTPT LFTEMDTLQQ DGDELEWKES ARWVKFEEKV EEGGERWSKP
HVSTLSLHSL FELRTCIQTG TVLLDLEGYS LPQIVDEIIE QQVDEGMLSP DLREKISFVL
LRKHRHQTKK PIHRSLADMG KASGGGAPRS PGAAAAFNRS TEDLRMKSQP GGYGRLRHAQ
SRSMNDISDT PSTDQLRNKF MKKIPRDAEA SNVLVGEVDF LDKPFVAFVR LAQATTLGGL
TEVPVPTRFL FILLGPTGKA KSYNQIGRAI ATLMVDDLFS DVAYKARDRE DLIAGIDEFL
DEVIVLPPGE WDPKIRIEPP KKVTSADKRK SVFSLNELGQ PNGAAGGGGG LAEDEEMPVA
HELGEELAHT GRFCGGLFLD IKRKIPWLLS DFYEGFHIQS ISAVLFIYLG CITNAITFGG
LLGDATDNYQ GVMESFLGTA LSGTVFCLFS GQPLIILSST GPILIFEKLL FEFSKNNGID
YMELRLWIGI HSCLQCFLLV ATDASYIIKY MTRFTEEGFS SLISFIFISD AIKKMMGSFK
YYPINTDFKP DYVTAYKCEC LAPDPSLDWS QLSKKECVKY GGSLVGNTCK YVPDLALMSF
ILFFGTYSMT VSLKKFKFSR YFPTKLRKLI SDFSIFMAIM TFVGLDRLIG LKTPKLIVPT
EFKPTRPDRG WIVLPFGKNP WWVYLASFVP ALLVTILIFM DQQISAVIVN RKENKLRKGC
GYHLDLFWVG VLMAACSFLG LPWYVAATVI SIAHIDSLKM ESESSAPGEQ PQFLGVREQR
LTGILVFVLT GVSIFLAPIL QFIPMPVLYG VFLYMGVASL SGIQFWERIK LYMMPSKYQP
DFPFLRHVPL RRVHLFTLVQ IICLAVLWVL KSTVLAILFP VMILGLLVVR KMLDMVFSQH
DLAWIDDILP GKDKKKEKKK KGDKDDTKKK DKKKGRSDDS EDEEKYHAYS NCSPSSESDV
DRSITLHLKI SCPSSPAVPM AHGRGMAFPV PQVKIEMESD YDTDTDHPRH RDMSSETTL
//
