ID A0A1S3NPB6_SALSA Unreviewed; 1731 AA.
AC A0A1S3NPB6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Dedicator of cytokinesis protein 8-like isoform X4 {ECO:0000313|RefSeq:XP_014017219.1};
GN Name=LOC106580556 {ECO:0000313|RefSeq:XP_014017219.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014017219.1};
RN [1] {ECO:0000313|RefSeq:XP_014017219.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014017219.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_014017219.1; XM_014161744.1.
DR OrthoDB; 5480873at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08696; C2_Dock-C; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF74; DEDICATOR OF CYTOKINESIS PROTEIN 8; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 194..366
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1269..1702
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 54..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1731 AA; 196593 MW; 6725B85BDD4DD7EE CRC64;
MVMKETDSAK NKEKLEKLRN QSEMFCQRLG RYRMPFAWAT VNIMNVISTA TLDRDTTDSD
SINGKSSSLE KRGQLPRRNS ERFGTMEDQC NMSAFKPATI TISTFCKQEG DRLSDEDLFK
FLADIKKFSS LQRRIKTIPG TIKLDVTPVH DNPVACLSTE LIPVKPLAEK NVRPVKEVLE
FPSSEVYVPH STYRNLLYVY PQRLNFVNRL TSGGRNITIK IQFMSGEDPS CVMPVIFGKS
NGPEFVQEVY TPVTYHNKSP DFYEEVKMAL PARLTERHHL LFTFYHISCQ QKQNQTGASE
TLIGYSWLPI LSTDRLQTGQ YCLPIALDRL PVNYSLHSPE RITPQVPPVK WMESHKGVFN
LEIQAVSSVH TQDNHLERFF TLCHALEGGV TFPLRVREEK IPENKLEHEL KLSIISLSSS
RLEPLVLYLH LVLDKLFTLI MQPMVIAGQT ANLAQIAFES VVSIVNSLHN SQELARDQQG
RNGLLATYLY WVFRLPDSNE LLSTGPGGAV PPTEGRYSTM GRASATTVGT MLLQSRIRSS
SNPDIPAPHS PEDTEVNNIL SAKGQNNPGS RMSTYVDVSS HPQSSTGGTR PSNRKQFHEE
LALQIVVSTG VCRENAYKYA WFFFELLVKS MAQHVSQLEK QDVPRRSRFS DRFKDDVTTI
VSVVTAEMGT ILVKQQKELE QAEKVNISLA FFLYDLLSLM DRGFVFILVK NYCNQMSAKT
VSMPTLISMR LEFLRILCSH EHYLNLSLYF SSPASAPVSP CPSISSQSSS SCSFQEQRIL
GLFELSQEFK QQHYLAGLLL TELSAALDME SEGGKVQRKA INATYSLLCA HDLDQRCTRP
EVRAKVATLY LPLVGIIIDS INYLDFTVSE ARGGKSKTGG SDEDPDNIPP INQSIAMAIA
GNPFNTLARN ALASMASVQS AKAVATLSAE TSRNLLVCFL WVMKNAERSL IQRWTVDMPS
AQLNRLLELL TICVSCFEYR GKRSSDKVST QALQKSQQAK MQLEDSLLRG IGARGEMMRR
AGGSDRAGQR VNLRWRKDLT QWRQTNDKHD KTKAELDQEA LISGNLATES NLIVLDLLET
IVQAVPLADC KDSVVGGVLR VLLHCLTCNQ STTFLSHCFS TLRALVVKFG DLLFEEEAEQ
CADLCQKVLQ HCSSPVDGNR SQACATLYLI MRYSFSSANN FSRVKMQVTM SLASLVGKSE
DFHEEYLRRS LRTILAYAEE DTEMQNTPLP SQVDELLRNL NSILSDTVKM REFQEDPEML
MDLMYRIAKG YQTSPDLRLT WLQNMAEKHK NRKCFTESAM CLVHAAALVA EYLSMLEDHK
YLPVGSVTFQ NISPNVLEES AVSDDILSPD EDGVCSGQYF TTSGLVGLLK QAAQLFCNGG
LYETVNEVYK IIMPVLEAHR DFRELVSTHE KLQRAFDNII QKGHKRMFGT YFRVGFYGAK
FGDLDEQEFV YKEPAITHLP EISHRLENFY SQCFGDALEM IKDSKDIDRS KLDANKAYIQ
ITYVEPFFDD YEMKDRLTNF EKNFNLRRFM YTTPFTKAGR PRGELNEQYK RKTILTTMHT
FPYIKTRINV IQKEEFDLTP IEVAIEDMQK KTRELAVATH REQPDAKMLQ MLLQGSVGAT
VNQGPLEVAQ VFLNEIPADP KLFRHHNKLR LCFKEFIMRC GEAVEKNKHL ITLDQKEYQQ
ELKKNYNRLR ENLRPMLERK IPELYKPIKP RLENRDSVKR LSFRRALEEN S
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