ID A0A1S3NR67_SALSA Unreviewed; 672 AA.
AC A0A1S3NR67;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Rap1 GTPase-activating protein 2-like isoform X7 {ECO:0000313|RefSeq:XP_014017696.1};
GN Name=LOC106580794 {ECO:0000313|RefSeq:XP_014017696.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014017696.1};
RN [1] {ECO:0000313|RefSeq:XP_014017696.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014017696.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014017696.1; XM_014162221.1.
DR AlphaFoldDB; A0A1S3NR67; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR Bgee; ENSSSAG00000072120; Expressed in actinopterygian pyloric caecum and 12 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 198..414
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 74295 MW; 0F65B8EE6157436C CRC64;
MTQSAEFFDM LERMQVPKSE ETKPHSQRSK DDYIPYPRIE DILEKGSPYP QVILPQFGGY
WIEDAEAPVG TPTSSESSFC EEDDGGGMSP AGGFGFRLEC NSSARAYRKH FLGREHMNYY
CTGSSLGNLI MSLKHEEAEG QEFLRIMLRS RTKTHHDRIS LAGLNQLPSV PQIAKLLCDD
VTGLKFNPVL YPRGSQLIVG YDEHEVNNTF KFGVIYQKFG QTSEEELFGN NEETPAFREF
LSVLGDNIEL NDFKGFRGGL DVSHGQTGSE SVYTVFRQRE MMFHVSTKLP FTEGDVQQLQ
RKRHIGNDIV AAVFQEDATP FVPDMIASNF LHAYVLVQVE NPGTEHTTYK VSVTAREDVP
PFGPPLPNPA VFKKGPEFRD FLLTKLINAE NACYKSDKFA KLEGRTRAAL LDNLHDELHR
QTQTTLGLGQ AGEEDKLENG GHGGLLESFK RAMRVRSHSM ETMVGSHRHR SPGVGGGVPA
SLSGGGLPQS TECTKSTFSP PMLSAKSPLK SPVKRRSGLF PRLHSSTESP SDRHARSDQK
TPDICPLGQE GRSETSSNPS SPEICPNKER PFLKLKDCNN SRPNISRSSS STSSFSSTTG
EGEALEELDT GIHPSIASSS VFSPFPSLSV ESQGSATPLI MCRSPTDVKS KMSPRSNLKF
RFDKMSHSTT SE
//
