ID   A0A1S3NUW5_SALSA        Unreviewed;       723 AA.
AC   A0A1S3NUW5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=GRB2-associated-binding protein 2 isoform X2 {ECO:0000313|RefSeq:XP_014019179.1};
GN   Name=gab2 {ECO:0000313|RefSeq:XP_014019179.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014019179.1};
RN   [1] {ECO:0000313|RefSeq:XP_014019179.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GAB family. {ECO:0000256|ARBA:ARBA00029462}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_014019179.1; XM_014163704.1.
DR   AlphaFoldDB; A0A1S3NUW5; -.
DR   STRING; 8030.ENSSSAP00000074288; -.
DR   PaxDb; 8030-ENSSSAP00000074288; -.
DR   OrthoDB; 2904117at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa20.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR046355; Gab1-4-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR   PANTHER; PTHR45960:SF1; GRB2-ASSOCIATED-BINDING PROTEIN 2; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          6..117
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          175..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          541..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          662..723
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..357
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..652
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        671..686
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..723
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  79856 MW;  09D3825DDF89F716 CRC64;
     MSGGGEIIFQ GWLRKSPPEK KLRRYAWKKR WFILRSGRMS GDPDVLEYYK NDHSKKPIRI
     IDLHCCEQVD AGLTFKRKEF QDSFVFDIKT SERTFYLVAE TEEEMNKWVR SICQLCGFNQ
     SEQNNHDGRS STAHMGRSLA ADLSSSLTPL TRERKSSAPV HSSQPVLFTF DVPVRHGGSH
     SHHGNHGNHG GSLSNSAPQD YLLLHQCMSR KTESARSASF SQVQHSSNLF VGSDSAMQKF
     SHGFSHCLNG MGAQLHGFYS LPKPGKHQLA SAVGPRSSTR PDSPQEGCYV LPRGYSSEGP
     NLDQSRLGDT DQQENEELYT FKTPCNTLAT GNDRNHSNDQ HSNDRNHSDE RSNDRQTDNY
     DLPTPPGSFY QIPRTFDKNH NVTPSGSESS SGPPPRPPKP SQGSESGRWG SPRSLGGQNG
     EVTTVIPRRN TLPAVENSRL HRGCSFETSS HHRPIYFNNQ GQSVECVNDG FSSYLRTKAP
     LTRSDSGDSE DNYVPMNPGS SPLNAAQADS PKNIYIPMSP GPHHFDFPGF SATLPARKGS
     TASLCHRPGR LSDVTPPPIN RNLKPNRKSK PTPLDLRNNG IIDELPFKSP ITMSWTRPMP
     MNSGGMSSQH CRPISTQSIT STDSADSEEN YVAMQNPAST SPAVSGTSSP APRKCGNVDY
     LALDFQPGSP SPHRKPSTSS VTSDEKVDYV QVDKEKTQAL QNTMQEWTDV RQSTDPAPKT
     VKS
//