ID A0A1S3NW38_SALSA Unreviewed; 373 AA.
AC A0A1S3NW38;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Ileal sodium/bile acid cotransporter {ECO:0000256|ARBA:ARBA00013351};
DE AltName: Full=Apical sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00032438};
DE AltName: Full=Ileal Na(+)/bile acid cotransporter {ECO:0000256|ARBA:ARBA00033223};
DE AltName: Full=Ileal sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00030792};
DE AltName: Full=Na(+)-dependent ileal bile acid transporter {ECO:0000256|ARBA:ARBA00033014};
DE AltName: Full=Solute carrier family 10 member 2 {ECO:0000256|ARBA:ARBA00031381};
GN Name=slc10a2 {ECO:0000313|RefSeq:XP_014019465.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014019465.1};
RN [1] {ECO:0000313|RefSeq:XP_014019465.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014019465.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) +
CC tauro-beta-muricholate(in); Xref=Rhea:RHEA:72179, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:133064; Evidence={ECO:0000256|ARBA:ARBA00034255};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) +
CC tauroallocholate(in); Xref=Rhea:RHEA:51840, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191406; Evidence={ECO:0000256|ARBA:ARBA00034234};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) +
CC taurochenodeoxycholate(in); Xref=Rhea:RHEA:71923, ChEBI:CHEBI:9407,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00034224};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) +
CC taurocholate(in); Xref=Rhea:RHEA:71875, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36257; Evidence={ECO:0000256|ARBA:ARBA00034239};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) +
CC taurodeoxycholate(in); Xref=Rhea:RHEA:72087, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36261; Evidence={ECO:0000256|ARBA:ARBA00034280};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) +
CC tauronorcholate(in); Xref=Rhea:RHEA:71915, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191405; Evidence={ECO:0000256|ARBA:ARBA00034291};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) +
CC tauroursodeoxycholate(in); Xref=Rhea:RHEA:71927, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:132028; Evidence={ECO:0000256|ARBA:ARBA00034230};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71911, ChEBI:CHEBI:29101, ChEBI:CHEBI:29747;
CC Evidence={ECO:0000256|ARBA:ARBA00034231};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2
CC Na(+)(in); Xref=Rhea:RHEA:71935, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29746; Evidence={ECO:0000256|ARBA:ARBA00034215};
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000256|ARBA:ARBA00011407}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
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DR RefSeq; XP_014019465.1; XM_014163990.1.
DR AlphaFoldDB; A0A1S3NW38; -.
DR STRING; 8030.ENSSSAP00000101088; -.
DR PaxDb; 8030-ENSSSAP00000101088; -.
DR Ensembl; ENSSSAT00000135605; ENSSSAP00000101088; ENSSSAG00000074732.
DR GeneID; 106581743; -.
DR KEGG; sasa:106581743; -.
DR CTD; 6555; -.
DR OMA; AHYVIMP; -.
DR OrthoDB; 3035577at2759; -.
DR Proteomes; UP000087266; Chromosome ssa21.
DR Bgee; ENSSSAG00000074732; Expressed in digestive tract and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0015850; P:organic hydroxy compound transport; IEA:Ensembl.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00841; bass; 1.
DR PANTHER; PTHR10361:SF19; ILEAL SODIUM_BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 327..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 373 AA; 40110 MW; 6CDE3C696FEBFC08 CRC64;
MNTPMTTAAV ALATCHTNAT ICSGTSCLVA PSNYNKNLSL VLSIVLTVML AMVMFSMGCT
VEAGKLWGHI KRPWGIFIGF LCQFGIMPFT AFALSLAFNV LPVQAVVIII MGCCPGGSSS
NIIAYWLDGD MDLSISMTAC SSILALGMMP LCLLIYTSVW TSADTIQIPY QSIGITLVSL
LIPVALGIYV KNKWPQTAKK ILKVGSIVGL LLIIIIAVVG GVLYQSSWTI SPSLWIIGAI
YPFVGFTLGF FMARFVGQPW HRCRTIALET GFQNSQLCST IVQLSFSPED LEVMFAFPLI
YSIFQLVVAV LSVGAYQMYK RKCGGGSSEL DSEGAEGDAE APPKDKQEYA LENGGFECDE
NGNNGGKGKI TQM
//
