ID A0A1S3NX05_SALSA Unreviewed; 1355 AA.
AC A0A1S3NX05;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ras/Rap GTPase-activating protein SynGAP-like isoform X13 {ECO:0000313|RefSeq:XP_014019927.1};
GN Name=LOC106581894 {ECO:0000313|RefSeq:XP_014019927.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014019927.1};
RN [1] {ECO:0000313|RefSeq:XP_014019927.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014019927.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014019927.1; XM_014164452.1.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF25; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 2.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 208..242
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 233..351
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 416..608
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 810..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1235..1294
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1355 AA; 152148 MW; 04B10B044CDA6034 CRC64;
MSYVPFQDAR CAVPPSYRPH APSFAAPSYD RPDWNPRLCV ISGNQLYMLD QEEVHPLLMR
ERRSELHRNK LLRRTVSVPV EGRHHPEMEN ARARRKSIAN VKQPSMEIPP TAPPQPFRQS
SFLSRRLKGS IKRAKSQPKL DRTSSFRHMI LPRFRSADQD RTRLMQSFKE SHSHESLLSP
SSAAEALDLT LDEDAIIKPV HSSILGQEYC FEVTTASGTK CFACRSGAER DKWIENLQRA
VKPNKDNSRR VDNVLKLWII EARELPTKKR YYCELCLDDM LYARTTSKPR TDTVFWGEHF
EFNNLPAVRN LRLHLYKETD KKRRKEKSTY LGLVSISISS ITGRQFVEQW YPVIQPSILA
KGQAGGKIIN ASLRLKSRYQ TMSILPMELY KEFAEYVTNN YRTLCAVLEP LLSVKSKEEV
ACALVHILQS TGKAKDFLSD MAMCEVDRFI DREHLIFREN TLATKAIEEY LKLIGHKYLK
DAIGEFIRAL YESEENCEVD PMRTPPSVLP DHQANLRMCC ELALCKIVNS HCVFPRELKE
VFASWRVRCA ERGREDIADR LISGSLFLRF LCPAVMSPSL FNLTQEYPDE QTSRTLTLIS
KVVQNLANFS KFGMKEEYMC FMNEFLEMEW GSMQQFLYEI SNLDSVSNAG GFEGYIDLGR
ELSILHSLLW EVMAQLSKSS NPNPQDAIIK LGPLPRLLND ISMALRNPHL QRQPSHQNQT
DRVHERQTER LLSRPSFNRG VSSEFQNLMM KDLNSSIDIT RLPSPTSGVS GGGVMPSRAH
PQLSFQERDH PHRASKDVFY VTRPPLARSS PAYCTSSSDI TEPDHKDSTM NSVSNLQSVA
MLNSSQASIT GMGSFGGLSS QGGGGLGSGL SGQLRAGGRL SAGSGGSSMS GGLRLSQLSQ
MGTTTDSLSQ QQQQQAAALR YPLSFQNPLF HLATGTADGP HLHHQHSRAH LPPPLLLAPE
PDPGGSHQAY IPQFAHGGFS RSEDLSTLRT GAGHLGQPAI IHSHSYSDDY SRADFARRQL
SMHGQDNLQQ QQQMGMASQT GTSHSSLATP PSTVQPVRQS SIAPPPAQRV KSQTSHQLSV
SAAAAPTPSA KTRPPSANLS PESGYGGRQQ APRQQLSVKD NTAPGLPHQQ SSVRESQGPQ
GPQGGTTTTI QQSQQQQQQP QQQHLLKPSI SKQGSGQSPS TLNPPTPANE RTVAWVSNMP
HLSADITLEA NRIDREEFKL KEYSKSMDES RLDRVKEYEE EIHSLKERLI MSHRKLEEYE
KRLLSQEQQT SKILSQYQSR LEDSERRLRQ QQVEKDSQIK GIINRLMAVE DEIRGGAIIE
PPKANVRVFA DQGRRQSILV QPRLAPVPPR VQRLH
//
