ID A0A1S3NXC8_SALSA Unreviewed; 798 AA.
AC A0A1S3NXC8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Neurogenic locus notch homolog protein 1-like isoform X3 {ECO:0000313|RefSeq:XP_014020058.1};
GN Name=LOC106581966 {ECO:0000313|RefSeq:XP_014020058.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014020058.1};
RN [1] {ECO:0000313|RefSeq:XP_014020058.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014020058.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_014020058.1; XM_014164583.1.
DR AlphaFoldDB; A0A1S3NXC8; -.
DR GeneID; 106581966; -.
DR OrthoDB; 3965077at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24173; ANKYRIN REPEAT CONTAINING; 1.
DR PANTHER; PTHR24173:SF74; UVEAL AUTOANTIGEN WITH COILED-COIL DOMAINS AND ANKYRIN REPEATS; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 2.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00004; NL; 2.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50258; LNR; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..798
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010284574"
FT TRANSMEM 262..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..68
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 69..112
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 481..513
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 514..546
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 293..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..425
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..766
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..789
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 88534 MW; 16FAC93C35A58515 CRC64;
MMLVLWTAVL LGLSRLCQVA AASPGGDLWA KCPSGQCKAK FGDGSCDKEC TEPECLRDGF
DCLRDKGHCN SGHIHYCRDH YANSYCDQGC ESAACGWDGS DCHRHHSPLW AKGTLLLHTH
VPLQHGTFSN SSLLWALSTL LQTPLKLRGT VPLDSSKDLF TFNPQQLEHL LAQASSDDSN
GSLLFLQVDN RPCSRLPSTC FPYAIEAANF LRAATSLTRV SVPSHPELKA IISVRGVGEE
IGGREEDPVE EKDETNGATP PWLWAVIGVA TGLVLALVLM VVLAIRRVRR RRAEREGGGE
RVRHRSTVTE NDSGANVAKA WAQHTPHREQ RGRTGREKDR NGIKKKKAKE AEKKRRRDPL
GEDAIRLRPL KKDLDIGSDT DFTQSSMEDI NTSIRDHRTQ EQKHYRSPPS HPQSPIQPPP
RGWERNAVPS PHHRTPNQSG SVQWCGPDGS VVLIRAVRSG LDRVVLELLR AGVPVNNTDH
TGRSALHWAC SVNHLSLTRT LTRYGAAVDL QDNKGETALF LSALHGCYDT ARFLLLNGAN
QDLSDRRGRR ALDVAREGIH HQVLELLLAH RVQRGPIPME QANDMLWDER ALLYSQWVNS
PGLPGRSASF SGVIGHRDMS SPPPSDWSMG RVQCPSPQNW RPQLNQSVTA LVTPRIMGRP
PRPISTLQEV TSEDEDRERP QEVPRAATPH FLLPQPAPRQ RSFSCTQNAL QRRSSSQQPE
PTYVALSEKI ANEPIERVIV VPPTDAPTQS NRRSIVNSSD NPNRAAPEIE TASFKKADQK
ARSEKLNNHM PDSKQTAL
//
