ID   A0A1S3NXK0_SALSA        Unreviewed;       717 AA.
AC   A0A1S3NXK0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 2 isoform X2 {ECO:0000313|RefSeq:XP_014019995.1};
GN   Name=LOC106581948 {ECO:0000313|RefSeq:XP_014019995.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014019995.1};
RN   [1] {ECO:0000313|RefSeq:XP_014019995.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014019995.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_014019995.1; XM_014164520.1.
DR   AlphaFoldDB; A0A1S3NXK0; -.
DR   GeneID; 106581948; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa02.
DR   Bgee; ENSSSAG00000073947; Expressed in actinopterygian pyloric caecum and 14 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF350; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 ISOFORM X1; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          80..204
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          237..496
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          605..688
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          207..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..225
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        561..600
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  80523 MW;  270125DB347153DC CRC64;
     MKESGQDGVC SFLVKFSKKL KACSRSGLVE TKGETSPMKT TWYCPLDLST VLEEEEDGVI
     YNVVVKQQHG APTSATSSSR SQCVKAGTEE KLVQHLLHSF AMGDSSFITI FLSTYRSFTS
     TKRVLDILID RLQHPPGEST KSQTRQPFNR AVCMVFSMWL SEYPEDFRSL GEPGLLLRLA
     PLLPSDPSGT EIRGRLLRLA EELSEQALLP DSSSDRTTPS LPADPTKFDP TNILGFPAGL
     IAEQLTKIET ELFVRLVPYH CLGSLWSQRD KKGREDVCWS VRATVRQFNR LANAVMASCL
     WPTQLRSQQR ACLLEKWISV AEECRARKNF SSLYAIVSAL QSNPVHRLRR TWLETDREAV
     RRYEELSNIF SEKDNYSQSR ELLKEEGTSK FANLDGKMTN RRQIGSSAQG TVPYLGIFLT
     DLTMLDTAVK DRLENGYVNF DKRRREFEVL AQIRLLQSSC KNGVFITDEA FLQWYQSVPS
     LNEEESYRLS NEIEVPCEPS SGRTLNPTVI ITRCPNLNSS RTSLVADSDS HFDFPSPVCH
     FLSKFTKHMK SPSVSCLDVD SSHPTNDPIP SALTPSTPVK SHRRSVSCGN NPTNNNKGSG
     PEMRIVRIRM DLQDGNMYRS ILVTSNDKTP TVISSALEKH SQDPKQAPRY ELIQLLPEGK
     ELVIPATGNV FYAMTSSSVD FLLCRQGGNT PFRSQPISTE TSATFPRIKA KGRRLFF
//