ID A0A1S3NXQ2_SALSA Unreviewed; 761 AA.
AC A0A1S3NXQ2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=POU domain protein {ECO:0000256|RuleBase:RU361194};
GN Name=pou2f1 {ECO:0000313|RefSeq:XP_014020031.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014020031.1};
RN [1] {ECO:0000313|RefSeq:XP_014020031.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014020031.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC subfamily. {ECO:0000256|ARBA:ARBA00008879}.
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DR RefSeq; XP_014020031.1; XM_014164556.1.
DR AlphaFoldDB; A0A1S3NXQ2; -.
DR GeneID; 106581965; -.
DR CTD; 323702; -.
DR OrthoDB; 4250502at2759; -.
DR Proteomes; UP000087266; Chromosome ssa21.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR045703; POU2F1_C.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR000972; TF_octamer.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR PANTHER; PTHR11636:SF47; POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR Pfam; PF19536; POU2F1_C; 1.
DR PRINTS; PR00029; OCTAMER.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361194};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 298..372
FT /note="POU-specific"
FT /evidence="ECO:0000259|PROSITE:PS51179"
FT DOMAIN 400..461
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 402..462
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 78934 MW; 7D47F80C248293D4 CRC64;
MADGGAASQD ESSGPDSRMS NPSETSKCAM ESQSGDGNTG VQTNGLDFQR QAVQATNAIT
NAHAQALLQQ SKSEDSGAIP TSVQQGVLPQ AQLMLAGGQI AGLTLSPAQQ QMFLQQAQAQ
LLAAAMQQQS ASQQSSTTGA SISASAATPI TQLPLSQPVQ ITSIPSVSTH LPGQLSQLGY
PYEMATFSSY LPQLQQLQQQ NLTMPQFVLV QPGHHIATQL QPGQFIISQT PQGQQSFLQA
QNLLTQLPQS QANLLQTQPS INLASQPATP SHTIAATPIQ PLSHSQTPPK RLDTPSLEEP
SDLEELEQFA KTFKQRRIKL GFTQGDVGLA MGKLYGNDFS QTTISRFEAL NLSFKNMCKL
KPLLEKWLND AVCAENLSSD LALSSPCGLG SPGLGMEGLN RRRKKRTSIE TNIRVALEKS
FLEQNQKPTS EEITIIADQL NMEKEVIRVW FCNRRQKEKR INPPSSGHSI TGTGSTPIKT
IFTPTSPLVA STASLVTSNT PTTLTLNPVM PLTSTSVSGL TLTGTTIGAT TNTASVISTA
PMVTAVTSST SLSSCPTALQ VTAAETGGTQ EHTVVTQAPS SLATNLGTGQ VMVAGPGLSA
ALQGAAQLPT SSSYASMAGL NPGLNPGLMA SSQFTPGGAL LSLAPGGLGG AINPAMLSNS
TLATIQGLWS ALASGGTLPI TSLDGSGNLL FANTSAGSTP NLVQPLFLNP QNLSLLTSNP
VSLVSAGAAG GGALQVTANH QVTTATVPVP VSTITTASKA Q
//
