ID   A0A1S3NXX0_SALSA        Unreviewed;       700 AA.
AC   A0A1S3NXX0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Interleukin-1 receptor accessory protein-like 1-B isoform X4 {ECO:0000313|RefSeq:XP_014020120.1};
GN   Name=LOC106582011 {ECO:0000313|RefSeq:XP_014020120.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014020120.1};
RN   [1] {ECO:0000313|RefSeq:XP_014020120.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014020120.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009752}.
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DR   RefSeq; XP_014020120.1; XM_014164645.1.
DR   AlphaFoldDB; A0A1S3NXX0; -.
DR   GeneID; 106582011; -.
DR   OrthoDB; 3994459at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa21.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00096; Ig; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11890:SF46; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1-A; 1.
DR   PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Receptor {ECO:0000313|RefSeq:XP_014020120.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..700
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010291823"
FT   TRANSMEM        362..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          6..136
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          164..234
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          244..352
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          405..561
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   700 AA;  80346 MW;  D8D344A000FBBAF2 CRC64;
     MRPPSPLLIL LYVTLSRAMK TVSKRGSVDL CTDWSVDYLK YRVLQGEPVR LKCALFYGYI
     RANYSQAQSV GLSLMWYRST GLGHGDFEEP ISFNGVRMSK EEDAIWFRPA DLQDVGLYSC
     VLRNSTYCMK VSMSLHVAEN DTDLCYNSDM RHMEKAELSK SKDITCPDIE DYIEPGKDPH
     ITWFKECRPK QWRASILQRR DSLSIREVKE DDIGNYTCEV TFGSFVVHRT TELTVTAPLT
     DKPPKILYPS ENKISNMELQ LGSALNLTCR AFFGYAGDAS PLIYWMKGEK FIEDLDEERI
     EESEIKVVRE HLGEQEVAIS LTIHSVEEGD LGNYSCYVEN GNGRRQASIQ LSRRELMYTV
     ELAGGLGAIV LLLLFLISLY KCYKIELMLF YRRHFGSDDL DGDNKDYDAY LSYTKVDPDQ
     WSQETKEEER FALEILPDVL EKHYGYKLFI PDRDLIPTGT YIEDVARCVD QSKRLIIVMT
     PNYVVRRGWS IFELETRLRN MLVTGEIKVI LIECAELRGI MNYQEVEALK HTIKTLTVIK
     WHGPKSNKLS SKFWKQLQYE MPFRRTEPML SHEPALDVSE QGPFGELQTV SAISMAAATS
     TAMATAHPEL RSSFHNSYHT TMRQKHYYRS YEYDLPPGGT LPPLSSLGNQ HTYCNIPLTL
     LNGQRPPAGK SREHSLEEEH TNHAMLPLLP RETSISSVIW
//