ID A0A1S3P0B8_SALSA Unreviewed; 589 AA.
AC A0A1S3P0B8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Caspase-8-like isoform X2 {ECO:0000313|RefSeq:XP_014021077.1};
GN Name=LOC106582462 {ECO:0000313|RefSeq:XP_014021077.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014021077.1};
RN [1] {ECO:0000313|RefSeq:XP_014021077.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014021077.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014021077.1; XM_014165602.1.
DR AlphaFoldDB; A0A1S3P0B8; -.
DR GeneID; 106582462; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000087266; Chromosome ssa21.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF5; CASPASE 10; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 4..81
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 94..161
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 326..452
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 482..569
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 281..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 65717 MW; 29E63714B40185EF CRC64;
MEMDFQRLLL QVEQALSSEE VQALAFLCKD LLEKDCSSVP TASKLFSLLM DQELLTPDQP
YLLADLLCTI QRHSLMRELG LNNQLPTTSS LISPYRKLLY DLSENTTEDD LREIKFLLIN
TLPRRILEDN VTTLQLFLEM EKVDILSVIK LNIVESMFGS VCPMLKTRIN QFKTQQGPVT
QKTGVGLLRS RSSSACLPEN QAVSMLPRRP VSCGLSVEQR GHSDTMFFPS SNFSSASQPS
TEVSTLNPAD TSLDVRRVSD TADTVLSHRL ALLSTSGDNN AALSQENHHV SSIPSRGHNK
NFDPANRQTG NTTKEDVGEY AMTGRKRGYC LIINNYNFRN SPKLLSNREG TQVDERSLVS
VFEWLGFETQ IEPDCSREQL LSLVAELRSR DHSQMDCLVC CVLSHGLEGG VYGVDGLKVR
VRELTEPFSG LECSSLRGKP KLFFIQACQG IKEQQPVFIQ SDCPGADGST TTSSICTDAV
VRRDSIPSDA DFLLGMATVP HFASFRDMSK GTWFIQSLCQ NLINLVPSGY DLLSILTKVN
DDVSNRSDNH GTRKQMPQPA YSLRKRLVFP IPKYPPPRLH LPDYTSQTT
//
