ID A0A1S3P0C0_SALSA Unreviewed; 574 AA.
AC A0A1S3P0C0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Caspase-8-like isoform X3 {ECO:0000313|RefSeq:XP_014021078.1};
GN Name=LOC106582462 {ECO:0000313|RefSeq:XP_014021078.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014021078.1};
RN [1] {ECO:0000313|RefSeq:XP_014021078.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014021078.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR RefSeq; XP_014021078.1; XM_014165603.1.
DR AlphaFoldDB; A0A1S3P0C0; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000087266; Chromosome ssa21.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF5; CASPASE 10; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 8..85
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 98..165
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 311..437
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 467..554
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 266..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 64071 MW; 5790DE9CB411BFCF CRC64;
MVLRQEMDFQ RLLLQVEQAL SSEEVQALAF LCKDLLEKDC SSVPTASKLF SLLMDQELLT
PDQPYLLADL LCTIQRHSLM RELGLNNQLP TTSSLISPYR KLLYDLSENT TEDDLREIKF
LLINTLPRRI LEDNVTTLQL FLEMEKVDIL SVIKLNIVES MFGSVCPMLK TRINQFKTQQ
GPVTQKTGVG LLRSRSSSAC LPENQAVSML PRRPVSCGLS ASQPSTEVST LNPADTSLDV
RRVSDTADTV LSHRLALLST SGDNNAALSQ ENHHVSSIPS RGHNKNFDPA NRQTGNTTKE
DVGEYAMTGR KRGYCLIINN YNFRNSPKLL SNREGTQVDE RSLVSVFEWL GFETQIEPDC
SREQLLSLVA ELRSRDHSQM DCLVCCVLSH GLEGGVYGVD GLKVRVRELT EPFSGLECSS
LRGKPKLFFI QACQGIKEQQ PVFIQSDCPG ADGSTTTSSI CTDAVVRRDS IPSDADFLLG
MATVPHFASF RDMSKGTWFI QSLCQNLINL VPSGYDLLSI LTKVNDDVSN RSDNHGTRKQ
MPQPAYSLRK RLVFPIPKYP PPRLHLPDYT SQTT
//
