ID A0A1S3P134_SALSA Unreviewed; 3075 AA.
AC A0A1S3P134;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=LOC106582632 {ECO:0000313|RefSeq:XP_014021343.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014021343.1};
RN [1] {ECO:0000313|RefSeq:XP_014021343.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014021343.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR RefSeq; XP_014021343.1; XM_014165868.1.
DR STRING; 8030.ENSSSAP00000102014; -.
DR PaxDb; 8030-ENSSSAP00000102014; -.
DR GeneID; 106582632; -.
DR KEGG; sasa:106582632; -.
DR OrthoDB; 22878at2759; -.
DR Proteomes; UP000087266; Chromosome ssa22.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18668; CD1_tandem_CHD5-9_like; 1.
DR CDD; cd18663; CD2_tandem_CHD5-9_like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 3.40.5.120; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR46850:SF2; -; 1.
DR PANTHER; PTHR46850; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9; 1.
DR Pfam; PF07533; BRK; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 343..407
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 427..487
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 525..699
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 839..1008
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 66..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2007..2041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2126..2165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2191..2216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2570..2604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2741..2766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2862..2907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2957..2976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2986..3075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2008..2041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2126..2143
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2580..2604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2741..2757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2862..2888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2988..3011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3012..3075
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3075 AA; 343506 MW; 8E207C27E554790E CRC64;
MHFSKLSWRF CVLGNKCREK AQCSATDALT GECCPDAVTV KRNMKIQKKD KQMSTTHLQK
YTPATAASNA TAQNAQTPFP RGTLGSKDQI RDLGGGQTNH CMANSKHPRM GEAGTSSASL
SPCAPASPLN SEEDDGGGGR WAKKKQKKKD KRGEPGSAWQ HKGLERDMKP NKKREQKEGK
ELLLRSFKEP RKVKAPKEVK RGRKPKVQAL PHPPSECKSA PSPPRQRGRK PRAQVFQGPV
PAEKKKKGKR KSEAVLQEAG GRENVAFLST LAIGGEESID PLDNTKRRSG RQVKRRKYNE
DLDFKVVDDD GETIAVLGTG RIPALNAATL TWQAEEPPED EANIIEKILS VRTVKKEASP
EDTTEESEEF YVKYRNFSYL HCKWATLEEL EKDPRIQQKI KRFRTKHAQM KHIFVEPNED
LFNPDYIEVD RVLEVAITTD TETGEEVTHY LVKWCSLSYE EATWELQEDV DPVKIREFEE
IKRIPEFKFV ERPQPDKWQK LDKSKDYRNG NQLREYQLEG MNWLLFNWYN RKNCILADEM
GLGKTIQSIT FLFEMFSMGL RGPFLIIAPL STITNWEREF RTWTEINVIV YHGSQISRQM
IHQYEMYHKD QQGNVVLGGY KFHGVITTFE MIMADCPELK KIHWRCVVID EAHRLKNRNC
KLLEGLKLMN LEHKVLLTGT PLQNSVEELF SLLNFLEPLQ FPSESLFLEE FGDLKTEEQV
KKLQAILKPM MLRRLKDDVE KNLAPKEETI IEVELTNMQK KYYRAILEKN FTFLAKGANQ
HNMPNLINTM MELRKCCNHP YLIKGAEEKI LDSFRKTHSP DAWDFQLQAM IQAAGKLVLI
DKLLPKLIAG GHKVLVFSQM VRCLDILEDY LIQRRYTYER IDGRVRGNLR QAAIDRFCKV
DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ AQARCHRIGQ SKAVKVYRLI
TRNSYEREMF DKASLKLGLD KAVLQDINRK GSLNGAQQMT KIEVEDLLRK GAYGALMDEE
DEGSKFCEED IDQILQRRTQ TITIETEGKG STFAKASFVS SGNRTDISLD DPNFWQKWAK
ITELEIDSKA EKESLVIDTP RVRKQTRHYN SFEDDELMEF SELDSDSEER PCRTRRFSER
NRRYLRAECF RVEKNLLIFG WGRWKDILTH GRFKWQLAER DMEVLCRALL VYCVRHYMGD
DKIKSFIWDL ITPAKDGHKQ DLQNHSGLSA PVPRGRKGKK LKNQLSVPEM KHADWLVNCN
PEVVLQDDSY KKHLKQHCNK VLLRVRMLYY LKAEVLGETA AQSLEGIPAS KLEVALPDID
YIEIPAGWWD AEADKSLLLG VHKHGYERYN AMRADSELCF LERVGMPDVT ALSAEQSGGE
VVADLTDSAC KSDDVKDDPE CNPEEGGVEK VDNKDETSSS NDAMDKHDSV GQDTLSVEMV
QESFGQEGME LKGRPLWPAG PALTARLRRL ITAYQRFMRR EPLRHDFLLP EGLGAGLGTM
SWQLGEEIRR CTVAAAEPDP LFLEWQRRWV MSEQRWTRRE QADFYRTVSS FGVVYDPEKK
TFDWIPFRSF ARLERKTDES LERYFSSFVS MCRTACRLPP RKDEGPLDHN LFVEPITEER
AARTLYRIEL LRKVREQVLR HPLLGPRLQL CRPSLYLPVW WECGKHDRDL LIGAARHGLS
RTDYYILNDP QLSFLEAHRN YVQKENHQGY QPSVHHAGMA PSPHHHPCCI YDTGLGQCHS
PQPPEYGPPA IPSSAIHFHS HPNVHGHPPE IVGTGPGGSL GMVSGPREGF LVCPPLDESL
ELASLQHEGL ASDSLHGKSA KEAFNGFPFN SAQGGQSMLN SYGVQGELTS EQSADMDPII
SGKLRSDVLV GSSEENGLMA PLLELEQELQ VPWESTDHTG TADVVGMFNE ADPILGAPAL
DTEFLDTEEL PGDGGREDGA GGVLDDCLGI PSSRSDPGEP LPSSFMLFKN IDVSEEEPAA
EHTNLSASPL PSYIPPPHLS LSHMTLHRHH HNQGDVEQPE EKLSDSDTVA HVPSPDEGEA
ERDVSFKFDK EEMSVDSPSL VGLEQGLDTS CIPCEDTLQE EPCYGMGMGS PVESCQVALE
RPGEETLERD TPLGPVEEGL LEEQVEEPLE ISPMDSQEEE PVDGPLEDFC KDKAPEGPFT
GPLDQYDVEP EAAFEGPAEA ESTLSEHTLP TVDATDTLPP SSSVPRPQPE PPLSPGVAGV
AQIKLEFPLD PESSESQSDI LEPDSTVLTP KLEQTEVLME VKDKIKEERP QTPASVVDSY
VEVAQFAVPM SMCEMPDSLQ DAREPTIAQL LQEKALYSFS EWPKDRVIIN RLDSICHAIL
KGKWPSSSQQ YDSPSSLANT CVPNIVHQRA GFISARVQPS QSLNFNIPAP PVTHLPKYKS
RDAGECSQGD WRLTSLPLLQ ERLVAPPYLP ELKRGRRAFE YKAEVLSKQC HTGENMPVTV
SNRGGALLLN GWQEAAMDLS KAGDLGIGGD AAATVGHMSH QVHPGARKLP ATQGSVGKDK
AGILQAGLIH PVTGQIVNGN LRCDDGIMRR RRGRRRNVEA VDIGSVTSRG MHVQEKQGRV
EVTSHSAVSS TSSPPEHPPG TSTPTLSEVV AIDREAANNG LMEWLRQNPN CSMEVPTFAP
SPGSAILHSF VERPKQRRHR CKDPTKLDVN SLTGEERVPV VHRSTGRRLG GAMAPAIKEL
SRWLDANTEY CVAPDWADVV KHSGFLPEGK FTRILTEPVC REQGPRRRGR RPRSEMPKPL
LSESPMGPLC MNGGLIGSMD LVSLQNLRNV QGIPLTGLMR FPHGFAVSAG EDAKNGLSML
PMMLHGIHGA PHMFSVQGLM GLPPTCSAST SSSTAAVTTT AASSSAASSP SRGPGQASSS
TGAEGSGIQS GTERKREEKQ QGAMGSHSIA AITTTTATSS SSGSHQAFNP FLIPGMSHGL
LYPHMFLPHG GVMALPGMPP ADSSSSPKTK KKRTREEGVV VVVEAGSHSH LQTDSGPPKK
HSDGQTGEST ADQARPEDRE QMEDNIQEEG TGHDTYDPPE VNPKKSVEEE SGTMEISLME
EEKLPEEESV SRGAE
//
