ID   A0A1S3P384_SALSA        Unreviewed;       926 AA.
AC   A0A1S3P384;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Cadherin-4 {ECO:0000256|ARBA:ARBA00041040};
GN   Name=LOC106582912 {ECO:0000313|RefSeq:XP_014022010.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014022010.1};
RN   [1] {ECO:0000313|RefSeq:XP_014022010.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014022010.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   RefSeq; XP_014022010.1; XM_014166535.1.
DR   AlphaFoldDB; A0A1S3P384; -.
DR   GeneID; 106582912; -.
DR   OrthoDB; 5306553at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa22.
DR   Bgee; ENSSSAG00000081638; Expressed in testis and 7 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 4.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR014868; Cadherin_pro_dom.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   PANTHER; PTHR24027:SF81; CADHERIN-4; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08758; Cadherin_pro; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   PRINTS; PR01820; DESMOCOLLIN.
DR   SMART; SM00112; CA; 5.
DR   SMART; SM01055; Cadherin_pro; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..926
FT                   /note="Cadherin-4"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010248249"
FT   TRANSMEM        744..766
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          179..286
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          287..401
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          402..516
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          517..624
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          623..730
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   926 AA;  101912 MW;  7AEB5A2E04478B28 CRC64;
     MNLGSVLILT CTLLVDTSWV TKADQPPKPP CRPGFSESFY TVFVSRDLLR GQSILKDTTL
     SSERVKFDDC QHSKAVDFES SDPNFSVRPD GSVYAEQEVA NLSEPVQFMV TARRGHDPHI
     WETTVKLALA GHPPSVPVSQ IGVEDMIARA WDSNPRVIKF PRKHQRSSSA NGLRRQKRDW
     VIPPINVPEN SRGPFPQMLV RIRSDQDLEK GIRYSITGAG ADQPPIDVYN IDPVHGKMFV
     TRPLDREERA SYHLRAHAVD MNGNKVESPI DLYIYVIDMN DNRPEFQNQV YNGSVAEGSK
     PGTLVMQVTA NDSDDDTTAN GMVRYRILSQ TPHMPIPNMF TINSETGDIF TVAAGLDREK
     VSQYTIIVQA TDMEGNLNFG LSNTATALIS VTDINDNPPE LTARTFSGEV PENRVNVVVA
     NLTVIDRDQP HSPNWAAQYR IASGDPQGHF LIRTNPVNND GMVTVVKPVD YEQNRAFMLT
     VIVSNKAPLA SGIQSSLQSS AGVTISVQDV NEPPVFPSNP KSIRFEEGVP AGTTLTVFAA
     QDPDLFIHQT VRYSKLSDPA SWLRINRTNG QITTMAVLDR ESMYVRNNIY EATFLAADNG
     SPPASGTGTL QIHLIDVNDN APVLFPKEAQ VCERASPRSR VNITASDADA DPHVGPFVFE
     LPSYPPSVRR NWTASRISGD YAQLRLRIPY LDAGVYDVPI IVSDSGNPPL SNRSMIKVKV
     CPCDDNGDCT TTGAVAAAGL GTGAIIAILI CIIILLTMVL VFVMWMKRRE KERQAKPLLI
     DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPEALDHII CKPTGVRRVD ERPVIAESQY
     PVRPSLPHPG DIGDFINDGL RAADNDPTAP PYDSLLVFDY EGSGSTAGSV SSLNSSSSGD
     QDYDYLNDWG PRFKKLADLY GGGDDD
//