ID A0A1S3P4X8_SALSA Unreviewed; 280 AA.
AC A0A1S3P4X8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=cathepsin X {ECO:0000256|ARBA:ARBA00012516};
DE EC=3.4.18.1 {ECO:0000256|ARBA:ARBA00012516};
GN Name=LOC106583261 {ECO:0000313|RefSeq:XP_014022688.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014022688.1};
RN [1] {ECO:0000313|RefSeq:XP_014022688.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014022688.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of C-terminal amino acid residues with broad
CC specificity, but lacks action on C-terminal proline. Shows weak
CC endopeptidase activity.; EC=3.4.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001594};
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_014022688.1; XM_014167213.1.
DR AlphaFoldDB; A0A1S3P4X8; -.
DR GeneID; 106583261; -.
DR CTD; 1522; -.
DR OrthoDB; 5475703at2759; -.
DR Proteomes; UP000087266; Chromosome ssa22.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02698; Peptidase_C1A_CathepsinX; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR033157; CTSZ.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF838; CATHEPSIN X; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 33..264
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 280 AA; 31310 MW; 4B09799E14B4E3F3 CRC64;
MAIQSLKSMK QSKPRVETRT LPRPHKFLKL NELPKTWDWR NINGTNYVST TRNQHIPQYC
GSCWAHGSTS AMADRINIKR KGAWPSAYLS VQNVVDCGEA GSCHGGDHSG VWEYANKHGI
PDETCNNYQA KDQKCKPFNQ CGTCTTFGVC NIIQNYTLWK VGDFGAINGR EKMMAEIYAG
GPISCGIMAT DKLDAYTGGL YSEYIEEPFI NHIVSVAGWG MDENGVEFWI VRNSWGEPWG
EKGWLRIVTS AYKGGSGSQY NLALEEDCMY GDPIVPKTYM
//
