ID A0A1S3P7Z9_SALSA Unreviewed; 676 AA.
AC A0A1S3P7Z9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
GN Name=LOC106583705 {ECO:0000313|RefSeq:XP_014023684.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014023684.1};
RN [1] {ECO:0000313|RefSeq:XP_014023684.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014023684.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR RefSeq; XP_014023684.1; XM_014168209.1.
DR AlphaFoldDB; A0A1S3P7Z9; -.
DR GeneID; 106583705; -.
DR KEGG; sasa:106583705; -.
DR OrthoDB; 537490at2759; -.
DR Proteomes; UP000087266; Chromosome ssa22.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF33; GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 83..166
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
FT REPEAT 592..612
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 676 AA; 75392 MW; 3BFEAD78C2A28AB1 CRC64;
MHCLKILRVT NAAAVETLKD TTKIVFKKVC YNGLLPCCRR NVKIQPAQYF NTSSTDQHRS
TTTSDMDHVL SKLSSGKGLF SEVEDILFYT ITEGQKQVPV SHFISALKRT GLNVSDPRLK
DCMDKLQRSV SESFHDVMMD RELFHKCVGG SIVLLIQAFR KKFIIPEFDS FVSKIDQIYN
TVQKNHNGHQ STFLTWPSSV LISGVCPCVQ WTDRGGYNLP VYSGRTEVGT TSLWTDRGGY
NLPVDGQRWV QPPCGRTEVG TTSLWTDRGG YNLPVDGQRH SVGDTKQPFC LQSCVKPLEY
AVAIHEAGTE KVHRYVGMEP SGLKFNMLYL DEEDKPHNPM VNAGAIVISS LIKPGSNKAE
KFDYMMDFIK KMAGREYVGF SNTTFQSEKE TGDRNFAIGY YLKEKKCFPT GAEMIDALDF
YFQLCSIEVT CESGSVMAAT LAHGGICPIT GERVLCAEAV RNTLSLMHSC GMYDFSGEMA
FHVGLPAKSG VSGAVLLVVP NVMGVMCWSP PLDRVGNSVR GIHFCQELVS SFNFHNYDNL
RHLVKKQDPR RQDGDDRNKS VVSLMFAAYS GDVSAVRRFA LSLMDMELKD YDSRTALHVA
AGEGHVDVVR FLTDACKVNP FLKDRWGNIP LDDAMQFGHS AVVKVLQDYQ AACQEQERLP
MADTIPLKLE TVEGMV
//
