ID A0A1S3P811_SALSA Unreviewed; 883 AA.
AC A0A1S3P811;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=LOC106583719 {ECO:0000313|RefSeq:XP_014023722.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014023722.1};
RN [1] {ECO:0000313|RefSeq:XP_014023722.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014023722.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010}.
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DR RefSeq; XP_014023722.1; XM_014168247.1.
DR AlphaFoldDB; A0A1S3P811; -.
DR STRING; 8030.ENSSSAP00000113355; -.
DR PaxDb; 8030-ENSSSAP00000113355; -.
DR GeneID; 106583719; -.
DR KEGG; sasa:106583719; -.
DR CTD; 4171; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000087266; Chromosome ssa22.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 455..661
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 883 AA; 99541 MW; 2E3766C8ADA97BFD CRC64;
MADSSESYHM ATSPSRGSRR GELTSSPGRD LPPFEDESEG LLGEGTLPEE EGDGEELIGD
AMERDYRAIP ELDRYEVEGL DLDEELSELS PGARAAAEDA MRRRDREQGG RLRRGLLYDS
EDEDEERPAR RRRLAERAAE GTGADDEEMI ESIENLEDMK GHSVREWVVM AAPRLEIYHR
FKNFLRTHVD ENGHNVFKEK ISDMCKENKE SLVVNYEDLA AREHVLAYFL PEAPTEMLKI
FDEAAKEVVL AMYPKYDRIA HEIHVRICNL PLVEELRSLR QLHLNQLIRT SGVVTCCTGV
LPQLGMVKYN CNKCNFILGP FFQSQNQEVK PGSCPECQSF GPFDINMELT VYQNYQRITI
QESPGKMAAG RLPRSKDAIL LADLVDQCKP GDEIELTGIY NNNYDGSLNM ANGFPVFATV
IMANHIARRD NKVAVAELTD EDIKAIVALS KDERIGERVF ASIGPSIYGH EDIKRGLALA
LFGGEPKNPG GKHKVRGDLN VLLCGDPGTA KSQFLKYVEK VASRAVFTTG QGASAVGLTA
YVQRHPVTRE WTLEAGALVL ADRGVCLIDE FDKMNDADRT SIHEAMEQQS ISISKAGIVT
SLQARCTIIA AANPIGGRYD PSLTFSENVD LTEPIVSRFD ILCVVRDTVD PVQDEMLARF
VVGSHIKHHP SNKEGGMAGL EEVVLPNTTD VPPIPQELLR KYIMYSKERV RPKLNQMDQD
KVAHIYSDLR KESMATGSIP ITVRHIESMI RMAEAHARMH LRDYVVEDDV NMAIRVMLES
FIDTQKFSVM RSMRKTFARY LAFRKDNNEL LLFILKQLVS EQVAYQRNRY GAQQDTIEIP
EKDLVDKARQ ISIHNLSAFY DSEAFRSNKF SHDMKKKLIL QQF
//
