ID A0A1S3PBG5_SALSA Unreviewed; 1455 AA.
AC A0A1S3PBG5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=ptpru {ECO:0000313|RefSeq:XP_014024912.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014024912.1};
RN [1] {ECO:0000313|RefSeq:XP_014024912.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014024912.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR RefSeq; XP_014024912.1; XM_014169437.1.
DR GeneID; 106584293; -.
DR CTD; 335096; -.
DR OrthoDB; 2875525at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14632; R-PTPc-U-1; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_014024912.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1455
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010328178"
FT DOMAIN 25..187
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 189..274
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 287..382
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 385..486
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 492..592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 903..1151
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1071..1142
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1183..1446
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1362..1437
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 818..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 163553 MW; 40DEEA347C21922A CRC64;
MNTCAFLLLL AVQIYAEGIE GPTAAGCTFD EDSEPSLCDF TQGEEDDFDW QLFRTHNSPY
ASSDLLCGSY MLVNSSQHAA GHRAQLLLQT LSENDTHCVQ FSYFLYSRDG HSPGALRAYV
RVNGGPLGSP VWNTSGSHGR QWHQVELAVS TFWPNEYQVL IEATVSRERR GYIAMDDILL
LTYPCYKAPH FSRLGDEEVN AGQNATFQCV ASGRASEAEK FLLERHSGDV TSTALVKHLS
HRRFVASFQV DSVQRNDQDL YRCVTQSSRG SGVSNFAELI VKVPPSPIAP PQLLRAGSTY
LIIQLNTNSI LGDGPIIRKE IEYRASQSPW SEVHGVNMVT YKLWHLDPDT EYHISVLLTR
PGEGGTGPPG PPLISRTKCA EPTRALRGLT ASEIQSRQLT LQWETLAYNL TRCHTYSVSL
CYRYATVGGG GGHNTTVREC LAVEHNASRF TLRDLPAYHS IRVRLALANP EGKKEGREVT
FQTEEDIPGG IAPESLTFTP LEDMIFLKWE EPVEPNGLIT QYEISYQSIE SSDPGINVPG
PRRTVSKLRN ETYHMFSNLH PGTTYLISVR ARTTKGFGQT ALTEITTNIS APMFDYGDMP
SPLSETESTI TVLLRPALGR GAPVSTYQVV VEEESGRKVK RELGVQDCYP LPMSHGEAQA
RGTPHYYTAE LPPSSLPEAS PFTVGDNHTY NGYWNTPLDP RKSYLVYFQA MSNFRGETRM
NCIRIARKAA CKDHRRALEV SQHSEEMGLI LGVCAGGLVV LILLLGAIII IIRKGKPVNI
NKTPITYRQE KSHMGSMERS FTDQSTLQED ERMALSAARM AHTCSTRSEQ RSSVNESSSL
LGGSPRRQCG HKGSPYHTGQ LHPAVRVADL LQHINQMKTA EGYGFKQEYE SFFDGWDCTK
KKDKTKGRHD TLMGCKSSWT CQPSCDESTD HHDRHRVKLH PLLGDPNSDY INANYIDGYH
RSNHFIATQG PKQETVYDFW RMVWQENCFS IVMITKLVEV GRVKCCKYWP DDSEMYGDIK
ITLLKTETLS EYTVRTFAME RRGYSAKHEV RQFHFTSWPE HGVPYHATGL LAFIRRVKAS
TPPDAGPVVV HCSVGAGRTG CYIVLDVMLD MAECEGVVDI YNCVKTLCSR RINMIQTEEQ
YIFIHDAILE ACLCGETAIL VNEFALTYKD MLRVDSQSNS SQLREEFQTL NSVTPHLDVE
ECSIALLPRN REKNRSMDVL PPDRALAFLV TTEGESNNYI NAALTDSFHQ PAAFIVTPHP
LPGTTADFWR LVFDYGCTSV VMLNQLNQSN SAWPCVQYWP EPGLQQYGPM EVEFLSTSAD
DDVITRLFRV KNVTRLQEGQ LVVCQFQFLR WSAYRDVPDS KKAFLSLLAH VHKWQRECGD
GRTVVHCLSG GGRSGTFCAS TILLEMIQYQ NMVDIFYSVK TLRNSKPNMV ESLDQYRFCY
DLILEYLDCI EDSMR
//
