ID A0A1S3PEC0_SALSA Unreviewed; 1942 AA.
AC A0A1S3PEC0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Uncharacterized protein LOC106584876 {ECO:0000313|RefSeq:XP_014025956.1};
GN Name=LOC106584876 {ECO:0000313|RefSeq:XP_014025956.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014025956.1};
RN [1] {ECO:0000313|RefSeq:XP_014025956.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014025956.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014025956.1; XM_014170481.1.
DR STRING; 8030.ENSSSAP00000029848; -.
DR PaxDb; 8030-ENSSSAP00000029848; -.
DR GeneID; 106584876; -.
DR KEGG; sasa:106584876; -.
DR CTD; 4437; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000087266; Chromosome ssa24.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 1143..1177
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1287..1473
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1514..1633
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1680..1802
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT REGION 127..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1782..1820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1195..1232
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 180..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1804..1820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1844..1863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1864..1909
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1942 AA; 217715 MW; E5C0927DD877FE9B CRC64;
MRLYIRKISV KMPKSIKKSC TTQTSISSYF GGLSSSASDR NVQSGIIGNS VELCAGLKPG
PRGKHKHSPN NNRGSLWKRA KLAHNGQEKE DMNCEVISWR VNEIRVPSSR GAGILSSSTL
ERLKGFVCPS EPQGRGPPGP RNAGGGPGDV GGRPGDVGGG CAHGGNGPGD VGGREAVAHG
EMTGDQERQK SEEEWRSPEP STKKQALSLI QFAKPGEGRR IRRGGVMKTP PGVGGEVSVT
SAPCRISKSG YTPLEQQYLQ IKEQHNDALL AVECGYKYRF FGEDAEKAAK QLNIFCHLDH
NFMTCSIPTH RLFVHVRRLV SQGYKVGVVK QTETSAIKAS GANKNTLFTR QLSALYTKST
LVGEDVNPVH SLVDVEEGEC DDVVTDPPES YLLCLSETWD KHRKQLIIGL VAVQPSTGDV
LLDCFVDGST RCELEGRVLK VKPVEILVPS DLSDSSHRLL QSIVTASVQA GDGVRIEKRD
SAQFDFASAM NTVTEFYCHT QDSGSRPLSS IASLESPVVC CLGPLIHYLT EFNLQRVLLH
HSSFRHLSCE SDGMVLSAPT LRNLEILTNQ TDGGMKGSLL WVLDHTHTSF GRRLMRKWVS
QPLKDAQSIC ERQFAVCEIL ESDAVTLPSV RALLFRLPDL ERGVCSIYHK KCSTQEFYLI
SSSLSRLGVE LQALLPSIQS QLSSTLLRGL LLDTPELLAP AHNFLKVLNE KAAKSGDKRE
LFCDLSGFPV LQGRRVEIQS VLTEIQDHRR EVRKTLRTPT LDYVRVSGQE FLIEVKNSMV
SVVPSDWVKI SSTKAVSRYQ SPYLIGRCRS LSQLREQLLI DSQKEWTNFL HQFGEYYHTM
KKAVGNLATV DCLFSLAEVA KQRNYCRPVL CEGDRQIVIR DGRHPVIDLL MGEHTQYVPN
NTELQGDGRR TLIISGPNMG GKSSYIRQVA LVSIMAQVGS YVPATEARLG ILDGIYTRMG
ASDSIYKGRS TFMEELTEAS EIVTRATERS LVILDELGRG TSTHDGIAIA YATLEYFIRD
VKSLTLFVTH YPPLCELEKV YPLHVGNFHM AFLLNEPDIT TDDIEVQPEF ITFLYQLTEG
AAGQSYGLNV ARLAEIPEAI LHIAARKAQE LKNIVDARRK SKRLFAELWR IDDRKALLDW
HYFLIVFGHD GQKPLELRTE EENECDEWVE AIQQASYSDI IIEREVLMQK YIHLVQIVET
EKVAANQLRT QLEDQDTEIE RLKGEIVALN KTNERMWPYH VNQEDEDPDI KKIKKVQSFM
RGWLCRRKWK LIVQDYICSP HAESMRKRNQ IVFNMVEAET EYVHQLSILV NCFLRPLRMA
ASSKKPPISH DDVSSVFLNS ETIMFLHEIF HQGLKARIAN WPTLVLADLF DILLPMLNIY
QEFVRNHQYS LQVLANCKQN RDFDKLLKQY EANAACEGRM LETFLTYPMF QIPRYIITLH
ELLAHTPHEH VERKSLEFAK SKLEELSRVM HDEVSDTENI RKNLAIERMI VEGCDILLDT
SQTFVRQGSL IQLPSVERGK LSKVRLGSLS LKKEGERQCF LFTKHFLICT RSSGGKLHLL
KQGGVLSLIE CTLIEETETS DDDSKSSGGQ VFGQLDFKLI IEPSDSPSFT VVLLAPSRQE
KAAWTSDISQ CIDNIRCNGL MTSVFEENSK VTVPHMIKSD MRLHKDDVDI CFSKTLNSCK
VPQIRYASVE RLLERLTDLR FLSIDFLNTF LHTYRIFTTA AVVMDKLADI YKKPFTSIPV
RVQYHSFDRL SITSICPDYS LKIRKIALDQ SKSLELFFAT NQNNRSGDHT NDKSPRLCRK
FSGPLSISSH TSSPVRTRKL SLHSPISARV GGLDLTNINS IPSSFSQSAV SSPTSAQTPT
FHPPTPQNST PQTPTTTSPP PTSSSPPPGG NRTPHEQAPL PPCLPLSYPE QSPSPTTEGQ
ELPRVDAFCG KLRRSIRRGH LE
//
