ID A0A1S3PEY9_SALSA Unreviewed; 1047 AA.
AC A0A1S3PEY9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN Name=LOC106584991 {ECO:0000313|RefSeq:XP_014026181.1,
GN ECO:0000313|RefSeq:XP_014026182.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014026182.1};
RN [1] {ECO:0000313|RefSeq:XP_014026181.1, ECO:0000313|RefSeq:XP_014026182.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014026181.1,
RC ECO:0000313|RefSeq:XP_014026182.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000256|ARBA:ARBA00009580}.
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DR RefSeq; XP_014026181.1; XM_014170706.1.
DR RefSeq; XP_014026182.1; XM_014170707.1.
DR GeneID; 106584991; -.
DR CTD; 101885659; -.
DR OrthoDB; 5490735at2759; -.
DR Proteomes; UP000087266; Chromosome ssa24.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR CDD; cd11652; SSH-N; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR014876; DEK_C.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR043587; Phosphatase_SSH-like.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR043588; SSH-N.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45864:SF5; PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 1; 1.
DR PANTHER; PTHR45864; SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG; 1.
DR Pfam; PF08766; DEK_C; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF109715; DEK C-terminal domain; 1.
DR PROSITE; PS51998; DEK_C; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 244..299
FT /note="DEK-C"
FT /evidence="ECO:0000259|PROSITE:PS51998"
FT DOMAIN 303..444
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 365..422
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 680..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1047 AA; 115688 MW; 5A75F99B86921062 CRC64;
MHLVVESPQE AVLKMLPYFV ENAVLTQSER CCILSESFFM VKGAALFLQQ GSSPQDQKAH
PHHKHAGDLP QHLQVMINIL RSEDRIKLAV RLESAWSDRV RYMVVVYTSG RQDTEENILL
GIDFSDKDSK SCSVGMVLPL WSDTKIHLDG DGGFSVNTVS RNHVFKPVSV QAMWSALQIL
HKVCEVSRRY NYFPGGMALT WMGYYESCIA SEQSCINEWN AMRDLETLRP DSPTMFVDKP
TERERTECLI KAKLRSIMMF QDLENVTSKQ IRTELEQHMS CNLMQYKEFI DNEMLLILGQ
MDKATLIFEH LYLGSEWNAS NLEELQDTGV GYILNVTREI DNFFPGTFSY HNIRVYDEED
TDLLAHWNET YNFIVKAKKN HSKCLVHCKM GVSRSASTVI AYAMKEYGWS LEKAFNFVKQ
KRSITRPNTG FMRQLAEYEG ILDASKQRHN KLWRPDRPDP DCDLHEGQQA QCCGGEDPGN
RTPEPGMSPC YEEKGAACPL SPCRMISLEV DPAYNNYYFR RLSDSALDSD PSTPVRALPL
LDMERVFIEI EDVERDALLD DEAFEGREGL PLPHFGLAGV GAAAQTSCRG PEPLEELRLR
LEFSTVEEED EEEVQKDEAE MEALAHPGGR LGSAGGGDGE GEVEMVQEEE VEKEGNGLDL
VTLNQNSNNN NHFNTLSRLN DTVPSKPAHP VKPSALSRSD NKPSHNIDSL TQDADLCLNP
THLPSVPSVS VEVPSATLPL PLTSPDTPCS LSLLHPCGPL CDCAAPPSTP LPEAQDSPCS
LTSEDMAGEA EGEEGKLLGV SEPLPVPELL GLSLEEKRPA VACYVTQQQE TLVQLQRSGL
VRRRAERLER LSGLSQEGLH PLEPLDSPHS GAREGPSPVE VEFSAFPEDF PKSSTPCPVS
LELLVVPLTN EALLGAVGSG GLTPNSSPHG STLTRSSSSD SIRSVRGKPG LVRQRAQEIE
TRMRLAGLTV PSSLKRSNSL AKLGSLNFSA EDLCSVCSSD AGTLLLLSLS PEPGLEWECP
STSSSAQPRA HRDQTTPERA LSGGPRS
//
