ID A0A1S3PFE4_SALSA Unreviewed; 970 AA.
AC A0A1S3PFE4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 1-like isoform X2 {ECO:0000313|RefSeq:XP_014026335.1};
GN Name=LOC106585074 {ECO:0000313|RefSeq:XP_014026335.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014026335.1};
RN [1] {ECO:0000313|RefSeq:XP_014026335.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014026335.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_014026335.1; XM_014170860.1.
DR AlphaFoldDB; A0A1S3PFE4; -.
DR STRING; 8030.ENSSSAP00000004331; -.
DR PaxDb; 8030-ENSSSAP00000004331; -.
DR GeneID; 106585074; -.
DR OrthoDB; 66005at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF530; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 1; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01464; EAGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..92
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 91..143
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 552..652
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 827..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 109101 MW; C688FBA2BB6FCB43 CRC64;
MAGGRRGLVA PQNTFLENIV RRSNDTNFVL GNAQIVNWPI VYSNDGFCKL SGYHRAEVMQ
KSSTCSFMYG ELTDKETGEK VQQIFENYEM NSFEILMYKK NRMPVWFFVT IAPIRNEQDK
VVLFLCTFSD ITAFKQPIED DSVKGWGKLA RLTRALTSSR GVLQQLAPTV HKGENVHKHS
RLAEVLQLGS DILPQYKQET PKTPPHIILH YCAFKTTWDW VILILTFYTA IMVPYNVSFK
TKQNNVTWLV VDSIVDVIFL VDIVLNFHTT FVGPAGEVIS DPKLIRMNYV KTWFVIDLLS
CLPYDVINAF ENVDEGISSL FSSLKVVRLL RLGRVARKLD HYIEYGAAVL VLLVCVFGLA
AHWLACIWYS IGDYEVIDEN TNSVRMDSWL YILSESGGTP YRFNASGSGR WEGGPSKDSV
YITSLYFTMT SLTSIGFGNI APTTDGEKLF AVAMMMIGSL LYATIFGNVT TIFQQMYANT
NRYHEMLNSV RDFLKLYQVP KGLSERVMDY IVSTWSMSRG IETDKVLQIC PKDMRADICV
HLNRKVFKEH PAFRLASDGC LRALAMEFQT THSAPGDLIY HAGESVDSLC FVVSGSLEVI
QDDEVVAILG KGDVFGDVFW KEVTLAQACA NVRALTYCDL HVIKRDALQK VLEFYTAFSN
HFSRNLLLTY NLRKRIVFRK ISDVKREEEE MLKRNNEAPL NLPPDHPVRR LFQRFRQQRE
ARLAVERTCQ GEPPDVEKGT VHLEQTKDHE VLASTSIIMV TESPATPTAS STSLSLSSRP
SSRVMLHAPA IQNGNLIGCK SAEPAPKTKK GWGCFKESVV KAGSWSSVSK AESMETLPDR
TKSHNEMSLK KTDSCDSGIT KSDLRLDNVS DSHTPQDRSS MQSEGKLVVC PIPVQTMHAS
FLELKQELRG DIGSLNGRMA VVEAQLAEML QLLKSKKASS SRKASHSSCF FEMSRPASPN
SHKDDSFSQP
//
