ID A0A1S3PFU2_SALSA Unreviewed; 968 AA.
AC A0A1S3PFU2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Sodium/calcium exchanger 1-like isoform X2 {ECO:0000313|RefSeq:XP_014026477.1};
GN Name=LOC106585125 {ECO:0000313|RefSeq:XP_014026477.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014026477.1};
RN [1] {ECO:0000313|RefSeq:XP_014026477.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014026477.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR RefSeq; XP_014026477.1; XM_014171002.1.
DR AlphaFoldDB; A0A1S3PFU2; -.
DR STRING; 8030.ENSSSAP00000003811; -.
DR PaxDb; 8030-ENSSSAP00000003811; -.
DR GeneID; 106585125; -.
DR OrthoDB; 462435at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878:SF69; SODIUM CALCIUM EXCHANGER 1H; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..968
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010360168"
FT TRANSMEM 83..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 870..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 398..498
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 529..629
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 968 AA; 107442 MW; 008B1536A7322FB5 CRC64;
MRQTGTSSFL FCTLQLAVLL AVFSSEIKFV TAGNSNPSLG TNSSIGNQTN KKCDSVDTEC
KVGVILPIWL PENPSFGDKL ARATVYFVAL FYMFLGVSII ADRFMASIEV ITSQEREITI
KKPNGEKVTT TVRIWNETVS NLTLMALGSS APEILLSVVE VCGHNFDAGD LGPNTIVGSA
AFNMFVIIGF CVSVIPDGEH RKVKHLRVFF VTATWSIFAY TWLYLILAVI SPGIVQVWEG
LVTLFFFPLC VGMAYVADRR LLVYKYMYKR YRAGKRRGVI IETEGEAQIP SKMDIEMDGK
MLNSESFMDG AMGFDEKDLD EEEARREMVR ILKELKQKHP EKETEQLIEL ANYQVLTQQQ
KSRAFYRCQA TRIMTGAGNV LKKHAADQAR KAVGAYEIRS EVSENDFSSK VFFDPGTYQC
LENCGTVALN VVRLGGDLTN TVSVEYRTED GTANAGSDYQ FTEGVVVFNP GETEKEIRID
IIDDDIFEED EHFLVHLSNV KVISEGTGYV QPRANHSDTL AGLGLPCSAT VTIFDDDHAG
IFTFEEPVMT ISESIGMMEV KVLRTSGARG LVVVPYKTME GTAKGGGEDF EDTHGALEFQ
NDEIFKTIQI NIIDDEEYEK NKNFFLEMGE PQLLEMSERK AVLLQEIGGF VKTGRDVYRK
VQGRDNPVPA TIISIAEEGD EEALSKKEEE ERRIAEMGRP TLGEHVKLEV VIEESYEFKN
TVDKLIKKTN LALLIGTNSW RQQFMEAITV NSGDDDEDEC GEEKLPSCFD YVMHFLTVFW
KLLFAFVPPT DYWNGWACFV VSISMIGLLT AFIGDLASHF GCTVGLKDSV TAVVFVALGT
SVPDTFASKV AAIQDQYADA SIGNVTGSNA VNVFLGIGVA WSIAAIYHNS KGNDFRVDPG
TLAFSVTLFT IFAFVAVAVL MYRRRPEIGG ELGGPRGPKI ATTCLFFSLW LMYIVFSSLE
AYCHIKGF
//
