ID   A0A1S3PGR8_SALSA        Unreviewed;       527 AA.
AC   A0A1S3PGR8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Succinyl-CoA:3-ketoacid-coenzyme A transferase {ECO:0000256|PIRNR:PIRNR000858};
DE            EC=2.8.3.5 {ECO:0000256|PIRNR:PIRNR000858};
GN   Name=LOC106585202 {ECO:0000313|RefSeq:XP_014026614.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014026614.1};
RN   [1] {ECO:0000313|RefSeq:XP_014026614.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014026614.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Key enzyme for ketone body catabolism. Transfers the CoA
CC       moiety from succinate to acetoacetate. Formation of the enzyme-CoA
CC       intermediate proceeds via an unstable anhydride species formed between
CC       the carboxylate groups of the enzyme and substrate.
CC       {ECO:0000256|PIRNR:PIRNR000858}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000858};
CC   -!- PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA
CC       from succinyl-CoA: step 1/1. {ECO:0000256|PIRNR:PIRNR000858}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase family.
CC       {ECO:0000256|ARBA:ARBA00007154, ECO:0000256|PIRNR:PIRNR000858}.
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DR   RefSeq; XP_014026614.1; XM_014171139.1.
DR   AlphaFoldDB; A0A1S3PGR8; -.
DR   GeneID; 106585202; -.
DR   KEGG; sasa:106585202; -.
DR   CTD; 442923; -.
DR   OrthoDB; 177109at2759; -.
DR   UniPathway; UPA00929; UER00894.
DR   Proteomes; UP000087266; Chromosome ssa24.
DR   Bgee; ENSSSAG00000059838; Expressed in muscle tissue and 14 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0008260; F:succinyl-CoA:3-oxo-acid CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046952; P:ketone body catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 2.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR012791; 3-oxoacid_CoA-transf_B.
DR   InterPro; IPR014388; 3-oxoacid_CoA-transferase.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004164; CoA_transf_AS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   NCBIfam; TIGR02429; pcaI_scoA_fam; 1.
DR   NCBIfam; TIGR02428; pcaJ_scoB_fam; 1.
DR   PANTHER; PTHR13707; KETOACID-COENZYME A TRANSFERASE; 1.
DR   PANTHER; PTHR13707:SF23; SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE; 1.
DR   Pfam; PF01144; CoA_trans; 2.
DR   PIRSF; PIRSF000858; SCOT-t; 1.
DR   SMART; SM00882; CoA_trans; 2.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
DR   PROSITE; PS01274; COA_TRANSF_2; 1.
PE   3: Inferred from homology;
KW   Mitochondrion {ECO:0000256|PIRNR:PIRNR000858};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000858}.
FT   ACT_SITE        353
FT                   /note="5-glutamyl coenzyme A thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000858-1"
SQ   SEQUENCE   527 AA;  57255 MW;  530EE20007273B27 CRC64;
     MAALKVLSRA ENLLLKNLSA TCRPNLNSIT HSMFKMCGCS YTTSSQRNSQ FYTDPTDAVK
     DIPSGATILV GGFGLCGIPE NLINSLLKTG VKSLTAVSNN AGVDNFGLGL LLQTKQIKRM
     ISSYVGENIE FERQYLSGEL EVELTPQGTL AERIRAGGAG VPAFFTATGY GTLIQEGGSP
     IKYNKDGTIA IASEQREVRE FNGRHYILEK AITGDFALIK AWKADKAGNV IFRKTARNFN
     QPMCKAAKVT IVEVEEVVDV GTFAEEDIHI PSIYIHRIIK GGSYEKRIER RTVQKAQAEK
     PKPKKDSDII RERIIRRAAL EFEDGMYANL GIGIPMLASN FIQPDITVHL QSENGILGLG
     PYPTEDEVDA DLINAGKETV TVLPGASYFS SDESFAMIRG GHINLTMLGA MQVSKMGDLA
     NWMIPGKMVK GMGGAMDLVA SAGTKVVVTM EHSAKGGKHK ILDTCNLPLT GKQCVDRIIT
     EKAVFDVDKT KGLTLIEVWE GLSPEDIKAC TGAHFAVSPN LRSMQQV
//