ID A0A1S3PH64_SALSA Unreviewed; 1774 AA.
AC A0A1S3PH64;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 3-like isoform X4 {ECO:0000313|RefSeq:XP_014026931.1, ECO:0000313|RefSeq:XP_014027712.1};
GN Name=LOC106585358 {ECO:0000313|RefSeq:XP_014026931.1};
GN Synonyms=LOC106585714 {ECO:0000313|RefSeq:XP_014027712.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014026931.1};
RN [1] {ECO:0000313|RefSeq:XP_014026931.1, ECO:0000313|RefSeq:XP_014027712.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014026931.1,
RC ECO:0000313|RefSeq:XP_014027712.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_014026931.1; XM_014171456.1.
DR RefSeq; XP_014027712.1; XM_014172237.1.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000087266; Chromosome ssa24.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF7; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 3; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_014026931.1,
KW ECO:0000313|RefSeq:XP_014027712.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 878..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 945..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1014..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1123..1148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 158..423
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
FT DOMAIN 888..1157
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1249..1303
FT /note="TRPM tetramerisation"
FT /evidence="ECO:0000259|Pfam:PF16519"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 807..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1534..1557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1616..1774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..830
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1616..1635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1639..1667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1753..1774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1774 AA; 200398 MW; 8E72685F60FB214F CRC64;
MASKKKWGDS RREGIRRDQA YSMREESSEG LGHPTTRGRF SESWKRLSSR GGSTKRSALN
SQQPPAQKSW IERAFNKREC VHIIVSAKDP HRCCCGRLIG QHVGLPPGIS SSQNDKTERL
AKNDSLSEKW SISKHTQLSP TDAFGTIEFQ GGGHSNKAMY VRVSYDTKPD LLLHLMTKEW
QLDLPKLLIS VHGGLQNFEL QPKLKQVFGK GLIKAAMTTG AWIFTGGVNT GVIRHVGDAL
KDHASKSRGK ICTIGIAPWG IVENQEDLVG KDVVRPYQTM SNPLSKLTVL NSLHSHFILA
DNGTTGKYGA EVKLRRQLEK HISLQKINTR IGQGVPVVAL IVEGGPNVIS IVLEYLRDTP
PVPVVVCDGS GRASDILAFG HKYSEEGGII NETLRDQLLV TIQKTFTYSR TQAQHLFIIL
MECMKKKELI TVFRMGSEGH QDIDLAILTA LLKGANASAP DQLSLALAWN RVDIARSQIF
IYGQQWPVGS LEQSMLDALV LDRVDFVKLL IENGVSMHRF LTLSRLEELY NTRHGPSNTL
YHLVRDVKKG NLPPDYRISL IDIGLVIEYL MGGAYRCNYT RKRFRTLYHN LFGPKRPKAL
KLLGMEDDMP IRRGRQKTTR KREEEVDIDL DDPEINHFHF PFHELMVWAV LMKRQKMALF
FWQHGEEAMA KALVACKLCK AMAHEASEND MVDDISQELN HNSSEFGQLA VELLDQSYKQ
DEQMAMKLLT YELKNWSNAT CLQLAVAAKH RDFIAHTCSQ MLLTDMWMGR LRMRKNSGLK
VILGLLLPPS ILSLEFKNKD EMSYMPQDQD TYLQEKEEEP EKPANEKEEE DMEFTAMLGK
VSTEASRKKG VGEVQNRHRL IPMGRKIYEF YNAPIVKFWF HTMAYVAYLM LFNYIVLVKM
DLWPSPQEWI VIAYIFTNGI EKMREILMSE PGKLLQKVKV WLQEYWNITD LMAILIFSVG
MVLRLQEPPL MSYGRVIYCV NIIYWYIRLL DIFGVNKYLG PYVMMIGKMM IDMMYFVIIM
LVVLMSFGVA RQAILNPNED PSWMLARNIF FMPYWMIYGE VFADQIDHVH SRKLKHRLNS
KLWMIENQFR AHGTWRNNAP CGQNITTEDG HVVALPPCKT GAWIVPAIMA CYLLVANILL
VNLLIAVFNN TFFEVKSISN QVWKFQRYQL IMTFYERPIL PPPLIIFSHM TMVLKHLCCR
WRKHDDDERD YGLKLFITED ELKKVHDFEE QCIEEYFREK DDRFNSSNDE RIRVTSERVE
NMAMRLEEVN EREHFMKSSL QTVDIRLAQM EELIGRIAVA LERVTGVERG EVNKARSRTS
SDCTDSAYML RQGECPDAAY ILRQSSFNSQ EGNSYRLNEG AEGSMSPPSP TGLATRTRSH
SFYVGGGRER AGADRAERAD RFLKERSFSL HRANSSQSVA SGTAPKESKP LPLATLSISQ
QHRPSSCIDI YVSASEEAGP AEVFSDPLRM APPLRHDSSL HSEIMEAVLS SGRDYSGGSG
LGDKHSEGGA MFEDSAAADL SLCSAHLLPD NTMPTWDLDS SPPPSAGPLE RSKSSRYLST
GGRGYLEETQ LVKSHSLMFT PRGCYGGLGA GVQVKAAEYT SITDCIDTRC VSAPYSTAER
SHSPGGSTSF PFNKPPDLGS SHPEREAELS HTESDPEDPE DLAPAPEPHR MGRGLRGASG
TPFCSPFSRL ERANSCSSDD SSHPSLAPPS HRKSLSVSER MERGADRGVL GGPRNPFLRS
KSGARPDTKT DSLSMRKLTT PSAFSSFDSR HNYT
//
