ID A0A1S3PIC5_SALSA Unreviewed; 2137 AA.
AC A0A1S3PIC5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN Name=LOC106585548 {ECO:0000313|RefSeq:XP_014027366.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014027366.1};
RN [1] {ECO:0000313|RefSeq:XP_014027366.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014027366.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_014027366.1; XM_014171891.1.
DR STRING; 8030.ENSSSAP00000118816; -.
DR PaxDb; 8030-ENSSSAP00000118816; -.
DR GeneID; 106585548; -.
DR KEGG; sasa:106585548; -.
DR OMA; QTEIQYY; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000087266; Chromosome ssa24.
DR Bgee; ENSSSAG00000080586; Expressed in sexually immature organism and 15 other cell types or tissues.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|RefSeq:XP_014027366.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Ribonucleoprotein {ECO:0000313|RefSeq:XP_014027366.1}.
FT DOMAIN 489..672
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 683..920
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1336..1511
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1571..1752
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 51..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..234
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2137 AA; 244015 MW; 6A0223DEAE51FE30 CRC64;
MADVTARSLQ YEYKANSNLV LQADRSLIDR TRRDEPTGEV LSLVGKLVGT KMGDKSQRTK
PSMLEERRAK RRKRDEDRHD MNKMKGFTLL SEGIDEMVGI VYKPKTKETR ETYEVLLSFI
QAALGDQPRD ILCGAADEVL AVLKNDKMRD KERRREVEQL LGPADDTRYH VLVNLGKKIS
DYGGDKELQN MDDNIDETYG VNVQFESDEE EGDEDQFGEV RDDGSDEESE GEEADLGCTL
TANLGVTGDV MTAKKKELHP RDIDAFWLQR QLSRFYDDAI ISQKKADEVL EILKTASDDR
ECENQLVLLL GFNTFDFIKI LRQHRRMIQY CTMLASAQSE AEKEKIIGKM ETDPDLSKVL
YQLQETEKED IIREERSRRE RVRKSRVDND LESMDIDHGE SMTPKQLLDL EDLAFTQGSH
FMANKRCQLP DGSFRKQRKG YEEVHVPALK PKPFADDEVL VTIEKLPKYA QAGFEGFKTL
NRIQSKLFKT AMESDENLLV CAPTGAGKTN VALMAMLREI GKHINLDGTI NLDDFKIIYV
APMRSLVQEM VGSFSKRLAS YGITVSELTG DHQLCKEEIN ATQVIVCTPE KWDIITRKGG
ERTYTQLVRL IIIDEIHLLH DDRGPVLESL VARTIRNVEL TQEDVRLLGL SATLPNYEDV
ATCLRVDPAK GLFYFDNSFR PVPLEQTYVG ITEKKAIKRF QIMNEIVYEK IMEHAGKNQV
LVFVHSRKET GKTARAIRDM CLEKDTLGLF LREGSASTEV LRTEAEQCKN LELKDLLPYG
FAIHHAGMTR VDRTLVEDLF ADRHIQVLVS TATLAWGVNL PAHTVIIKGT QVYSPEKGRW
TELGALDILQ MLGRAGRPQY DTKGEGILIT SHGELQYYLS LLNQQLPIES QMVSKLPDML
NAEIVLGNVQ NAKDAVNWLG YTYLYVRMLR NPTLYGVSHD DRSSDPLLER RRMDLIHTAA
NVLDKNSLVK YDKRTGAFQV TDLGRIASHF YITHDSIQTY NQLLKPTLSE IELFRVFSLS
SEFRNITVRE EEKLELQKLL ERVPIPVKES IEEPSAKINV LLQAYISQLK LEGFALMADM
VYVTQSAGRL MRAIFEIVLS RGWAQLTDKT MNLCKMIDKR MWQSMSPLRQ FRKLPEEVIK
KIEKKNFPFE RLYDLNHNEI GELIRMPKMG KTIHKYVHQF PKLDLAVHLQ PITRSTLKVE
LTITPDFQWD DKVHGSSEAF WILVEDVDSE VILHHEYFLL KAKYAQDEHL VTFFVPVFEP
LPPQYFIRVA SDRWLSCETQ LPVSFRHLIL PEKYPPPTEL LDLQPLPVTA LRNAAFETLY
QNKFPFFNPI QTQVFNAVYN SDDNVFVGAP TGSGKTICAE FAILRMLLHN AEGRCVYITP
MEALAEQVFV DWHQKFQDAL NKKVVLLTGE TSTDLKLLGK GDIIVSTPDK WDILSRRWKQ
RKNVQNVSLF IVDETHLIGG ENGPVLEVIC SRMRYISSQI ERPIRIVALS SSLSNAKDVA
HWLGCSTTAT FNFHPNVRPV PLELHIQGFN VSHTQTRLLS MAKPVYHAIM KHSPSKPAVV
FVPSRRQTRL TAIDILTFCA ADVVPQRFLH CTEKDLAPFL EKVTDGTLKE TLANGVGYLH
EGLSTTERRI VEQLFNSGAV QVVVASRSLC WGTNISAHLV VIMDTQYYNG KIHAYVDYPI
YDVLQMVGKA NRPLQDDEGR CVIMCQGSKK DFFKKFLYEP LPVESHLDHC MHDHFNAEIV
TKTVENKQDA VDYLTWTFLY RRMTQNPNYY NLQGMSHRHL SDHLSELVEN TLHDLEQSKC
ISIEDEMDVA PLNLGMIAAY YYINYTTIEL FSMSLNAKTK IRGLIEIISN AAEYKNIPIR
HHEDNLLRQL AQKVPHKLNN PKFNDPHVKT NLLLQAHLSR MQLSAELQSD TEEILSKAVR
LIQACVDVLS SNGWLSPALA AMELAQMVTQ AMWSKDSYLK QLPYFTSEHI KRCMDKGVES
IFDIMEMEDE DRSGLLQLSD TQIADVARFC NRYPNIELSY EVAEKENIKS GGPVLVLVQL
EREEEVTGPV IAPLFPQKRE EGWWVVIGDP KSNSLISIKR LTLQQKAKVK LDFVAPVLGV
HNYTLYFMSD AYMGCDQEYK FSVDVKEADS DGDSDSD
//
