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Database: UniProt
Entry: A0A1S3PIE1_SALSA
LinkDB: A0A1S3PIE1_SALSA
Original site: A0A1S3PIE1_SALSA 
ID   A0A1S3PIE1_SALSA        Unreviewed;       814 AA.
AC   A0A1S3PIE1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-JUN-2019, entry version 18.
DE   SubName: Full=ral guanine nucleotide dissociation stimulator-like isoform X4 {ECO:0000313|RefSeq:XP_014027154.1};
GN   Name=LOC106585456 {ECO:0000313|RefSeq:XP_014027154.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014027154.1};
RN   [1] {ECO:0000313|RefSeq:XP_014027154.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014027154.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
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DR   RefSeq; XP_014027154.1; XM_014171679.1.
DR   GeneID; 106585456; -.
DR   OrthoDB; 940219at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; -; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR015758; RalGDS.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; PTHR23113; 1.
DR   PANTHER; PTHR23113:SF35; PTHR23113:SF35; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; SSF48366; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-
KW   ProRule:PRU00168, ECO:0000256|SAAS:SAAS01081641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN       83    213       N-terminal Ras-GEF. {ECO:0000259|PROSITE:
FT                                PS50212}.
FT   DOMAIN      252    517       Ras-GEF. {ECO:0000259|PROSITE:PS50009}.
FT   DOMAIN      698    785       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   REGION      545    673       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3PIE1}.
FT   COILED      121    141       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    545    560       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3PIE1}.
FT   COMPBIAS    573    594       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3PIE1}.
FT   COMPBIAS    612    673       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3PIE1}.
SQ   SEQUENCE   814 AA;  91567 MW;  32CC5979F7E286B7 CRC64;
     METKSLSSFH KALAQPVKMC MFDFPVNILD DLNSTQEIGE EVEEGAVFTI TLRKVQLHQS
     ASKGQRWLGV ETDSALSLYE TCKVRTIKAG TLERLVEYMV SAFRGKDSTY VTIFLCTYRS
     FATTKEVLDL LLNRYANLQN QPGIDVHRHT QDDSTELRNT VSSILGAWLD QYSEDFWSPP
     QYSCLHHLMS YLHHHFPGSD LERRARNLLA LLHRRQQCEP DLDVEHIGCP FATQEESGFE
     DELPALNFLF FDPIMVAEQF TLMDADLFKK VVPYHCLGGI WSQRDKKGKE HLAPTIRATV
     AQFNCVTNCV ITTCLSNPCL KPTQRARLVE RWIEVARECR ILKNFSSLRA ILSGLQCNSL
     HRLKRTWDEV SRENFRTFRE LSEIFSDDNN YSLSRELLVK EGTSKFATLE INPKRAQRRH
     QQQRDLGVMQ GTIPYLGTFL TDLVMMDTAM KDYTESGLIN FEKRRKEFEV IAQIKLLQLA
     SNNYSFTQDS FFREWFSGVE RLSEAESYTL SCEIEPLSES SSNTTRAKKN GGIMKRWSDR
     QLTEASCSSA GSSHSKLFDQ SHIRPYQRGG GDSGDTLSVT SAGSSGSDLE DVNASFLSDS
     PDAHERKTST SSVKHSVSAL GKESQTREPN STFWESTSLS SLDTSGMGSG SGSSSASSSS
     VSSTTPLPGA SRSHKRSVSA VSCYSTLSLP LYNQQVDDCC IIRVSLDVDN GNMYKSILVT
     SQDKTPAVIS KAMVKHNLER EKTEDYELMQ KISEEKELRI PNNANVFYAM NSTANYDFVL
     KKRGLSKKGR AKSVASSTLP RMKQKGLKIA KGIF
//
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